Effects of Lifestyle Measures and Conventional Therapy in Gout

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Source: Lippincott's Bone and Joint Newsletter - Category: Orthopaedics Tags: CME Article Source Type: news

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Why the hell do PCPs refer podiatrists patients with Chronic gout? It’s called medical management Dr. PCP MD. What am I going to offer the patient? Why the hell do PCPS refer podiatrists patients with general neuropathic pain? I’m not talking neuroma or tarsal tunnel. I’m talking about chronic neuropathic pain. Why can’t their PCP order an EMG and medically manage the patient? If they can’t do that then why can’t they refer to neurology? Why does it take a podiatry visit to put that all... Podiometric Referral Patterns
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Podiatric Residents & Physicians Source Type: forums
Gout has been associated with weaker foot/leg muscles and altered gait patterns. There is also evidence of on-going foot pain and an increased risk of tendinopathy, with the Achilles and patella tendons most f...
Source: BMC Musculoskeletal Disorders - Category: Orthopaedics Authors: Tags: Research article Source Type: research
AbstractGout is the most common inflammatory arthritis affecting nearly 4% of adults (9.2 millions) in the U.S. Initiation of urate ‐lowering therapy (ULT) is strongly recommended for all patients with tophaceous gout, radiographic damage, or frequent gout flares. While allopurinol is the first‐line ULT, some patients do not tolerate or adequately respond to allopurinol and require a different ULT such as febuxostat. At the time of approval of febuxostat in February 2009, the U.S. Food and Drug Administration (FDA) mandated a post‐marketing cardiovascular safety trial (the CARES trial) to address concerns related to ...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: LETTER TO THE EDITOR Source Type: research
ConclusionsTo our knowledge, this is the first study employing a transdisciplinary clinical approach to examine therapeutic applications of tobacco by an Amazonian tabaquero. Our findings significantly contribute to the growing research literature on Amazonian medicine and emergent psychedelic-assisted therapies and could, in the long-term, open new treatment avenues in several domains. Forthcoming studies should assess toxicity/safety and clinical outcomes of patients receiving Amazonian tobacco-based treatment.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Abstract Goose hemorrhagic polyomavirus (GHPV) is the etiological agent of hemorrhagic nephritis enteritis of geese (HNEG), a fatal disease that impacts geese and has been recorded only in Europe. The present study describes the first clinical cases of HNEG in Taiwan and the phylogenesis of Taiwanese GHPV, and it elucidates the pathogenesis of GHPV infection using in situ hybridization (ISH). The genomes of Taiwanese GHPV were highly similar to the previously reported strains. The diseased geese showed various degrees of vascular damage, especially in the digestive tract. The affected geese in the early stage show...
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research
AbstractThe ABCG2 protein has a key role in the transport of a wide range of structurally dissimilar endo ‐ and xenobiotics in the human body, especially in the tissue barriers and the metabolizing or secreting organs. The humanABCG2 gene harbors a high number of polymorphisms and mutations which may significantly modulate its expression and function. Recent high ‐resolution structural data, complemented with molecular dynamic simulations, may significantly help to understand intramolecular movements and substrate handling, as well as the effects of mutations on the membrane transporter function of ABCG2. As reviewed h...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: REVIEW Source Type: research
Authors: Stamp LK, Taylor W, Gaffo A Abstract Gout is common in people with chronic kidney disease (CKD) and its treatment is frequently suboptimal in this special population due to concerns over adverse events and/or efficacy of medications. There is controversy about the use of urate-lowering therapy (ULT) in those with CKD and lack of agreement about the dosing of allopurinol, the recommended first-line ULT1,2. PMID: 33004535 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
CONCLUSION: OUD-hospitalizations increased in all 5 musculoskeletal diseases studied, but the rate of increase differed. Awareness of these OUD-hospitalization trends in 5 musculoskeletal diseases among providers, policy-makers and patients is important. Development and implementation of interventions, policies and practices to potentially reduce OUD-associated impact in people with rheumatic diseases is needed. PMID: 33004531 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
ObjectiveTo investigate the existence of distinct classes of gout flare trajectories and compare their gout ‐specific, comorbid, and sociodemographic characteristics.MethodsIn a prospective cohort study, adults with gout who were registered with 20 general practices self ‐reported the number of gout flares experienced at baseline and after 6, 12, 24, and 36 months via postal questionnaires. Latent class growth analysis (LCGA) was used to identify distinct gout flare trajectory classes. Statistical criteria and clinical interpretability were used to decide the opti mal number of classes. Baseline comorbidities, medicati...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
CONCLUSIONS: The associations between vitamin C, dietary fiber and alcohol intakes and hyperuricemia in men support the Dietary Approach to Stop Hypertension (DASH)-based approach and attention to alcohol intake for managing hyperuricemia in Korean men. PMID: 32990622 [PubMed - in process]
Source: Asia Pacific Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Asia Pac J Clin Nutr Source Type: research
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