Stem Cells for the Treatment of Intervertebral Disk Degeneration

Low back pain and neck pain are the first and fourth leading causes, respectively, of years lived with disability. The treatment of intervertebral disk degeneration remains a significant challenge. While there are still many obstacles to overcome, the use of stem cells for the treatment of disk degeneration has emerged as one of the most promising and exciting techniques to restore the structure and function of the degenerated disk. The use of stem cells in treating intervertebral disk disease as well as the obstacles that remain are reviewed here in an evidence-based manner.
Source: Techniques in Orthopaedics - Category: Orthopaedics Tags: Symposium Source Type: research

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Abstract Intervertebral disc (IVD) has a pivotal role in the maintenance of flexible motion. IVD degeneration is one of the primary causes of low back pain and disability, which seriously influences patients' health, and increases the family and social economic burden. Recently stem cell therapy has been proven to be more effective on IVD degeneration disease. However, stem cell senescence is the limiting factor in the IVD degeneration treatment. Senescent stem cells have a negative effect on the self-repair on IVD degeneration. In this review, we delineate that the factors such as telomerase shortening, DNA damag...
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
In this study, we analyzed FGF21 levels and alterations in the expression of genes encoding components of the FGF21-responsive molecular machinery in adipose tissue from aged individuals so as to ascertain whether altered FGF21 responsiveness that develops with aging jeopardizes human health and/or accelerates metabolic disturbances associated with aging. We studied a cohort of 28 healthy elderly individuals (≥70 years) with no overt signs of metabolic or other pathologies and compared them with a cohort of 35 young healthy controls (≤40 years). Serum FGF21 levels were significantly increased in elderly indiv...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The intervertebral discs of the spine are one of many small body parts that one will never put any thought into until they start to fail, at which point pain and disability ensure that they are never far from mind. One section of the large regenerative medicine community is focused on the spine and its supporting tissues; this open access paper is a review of approaches intended to repair damaged and worn intervertebral discs, from the expected stem cell therapies to more esoteric and novel options. This is all work in progress, and sadly it remains the case that benefits for patients as a result of these lines of work are...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Study Design. A systematic review and single-arm meta-analysis of clinical trials. Objective. To assess the efficacy of mesenchymal stem cells or chondrocyte in patients with discogenic low back pain. Summary of Background Data. There is no previous review evaluated the efficacy of mesenchymal stem cell or chondrocyte therapy in adults with discogenic low back pain. Methods. A comprehensive literature search was conducted on PubMed, Ovid MEDLINE, Ovid EMBASE, EBSCO, and Web of Science from database inception through on September 10th, 2015. We included clinical trials that evaluated stem cells or chondrocyte-bas...
Source: Spine - Category: Orthopaedics Tags: Literature Review Source Type: research
Degenerative disc disease (DDD) is a common cause of lower back pain with radicular symptoms and has a significant socioeconomic impact given the associated disability. Limited effective conservative therapeut...
Source: Journal of Translational Medicine - Category: Research Authors: Tags: Research Source Type: research
If you teach health law, come to the 40th Annual Health Law Professors Conference, June 8-10, 2017, at Georgia State University College of Law in Atlanta.  Here is the schedule: Thursday, June 8, 20178:00-12:00 AM Tour of the Centers for Disease Control and Prevention (Separate registration is required. Participants meet in the lobby of Georgia State Law to take a shuttle to the CDC.) 9:45 – 11:15 AM Tour of Grady Health System (Separate registration is required. Participants meet in the lobby of Georgia State Law and will walk over to Grady as a group.) 2:00 – 5:00 PM Conference Registration – Henso...
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care syndicated Source Type: blogs
Spinal device developer Intralink-Spine today released 1-month clinical results from a trial of its Réjuve system, touting early reduction of lower back pain in its 4 safety study patients. Rejuve is an injectable crosslinking device designed to mechanically strengthen and stabilize spinal discs and joints to reduce pain, according to the company’s site. “Patients experienced an average Visual Analog Scale pain score reduction of 92% and an average Oswestry Disability Index disability reduction of 88% at the 1-month interval. These positive one-month data are great news, especially as we move forward to ...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Clinical Trials Spinal Intralink-Spine Source Type: news
Authors: Shang J, Wang H, Fan X, Shangguan L, Liu H Abstract Low back pain is a prevalent disease, which leads to suffering and disabilities in a vast number of individuals. Degenerative disc diseases are usually the underlying causes of low back pain. However, the pathogenesis of degenerative disc diseases is highly complex and difficult to determine. Current therapies for degenerative disc diseases are various. In particular, cell-based therapies have proven to be effective and promising. Our research group has previously isolated and identified the cartilage endplate‑derived stem cells. In addition, alternativ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Authors: Hsu E, Murphy S, Chang D, Cohen SP Abstract INTRODUCTION: It is difficult to overestimate the personal and socioeconomic impact of chronic low back pain (CLBP). It is the leading cause of years lost to disability and poses the highest economic toll among chronic illnesses. Despite the strong need for extensive research efforts, few drugs have consistently demonstrated effectiveness for this condition. AREAS COVERED: In this review, the epidemiology, rationale for mechanism-based treatment, competitive environment and market trends, and the preclinical and clinical evidence supporting over 15 different ...
Source: Expert Opinion on Emerging Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Emerg Drugs Source Type: research
Your achievements A massive thank you to everyone who ran, hosted coffee mornings and bake sales, jumped out of planes and trekked across the country and indeed the world to fundraise for us. More than 1,300 of you took on a challenge or donated your time and fundraising skills in 2015. Together, you raised over £780,000! If you’d like to join Team A in 2016 and help raise money for our work, have a look at our events or contact localfundraising@arthritisresearchuk.org Improving care for people with arthritis In 2015 we continued to support healthcare professionals to provide the best care to people with art...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news
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