Melatonin: A review of its potential functions and effects on neurological diseases.

CONCLUSIONS: In this review, biological and chemical knowledge of melatonin, its experimental effects, and the clinical impact on patients with neurological disorders were described. According to all of the beneficial results obtained from experimental and clinical trials, melatonin may have a prophylactic and therapeutic effect on neurological diseases. Strong collaboration between neurologists and health service policy makers is needed to encourage use of melatonin in the patients suffering from neurological diseases. Melatonin may be the solution we have been looking for. PMID: 31718830 [PubMed - as supplied by publisher]
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

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Conclusions: After propoxyphene market withdrawal, many individuals experienced abrupt discontinuation of opioids. Policymakers might consider supporting appropriate treatment transitions and monitoring responses following drug withdrawals.
Source: Medical Care - Category: Health Management Tags: Original Article Source Type: research
Publication date: Available online 11 December 2019Source: Trends in GeneticsAuthor(s): Lindsey D. Goodman, Nancy M. BoniniThe presence of microsatellite repeat expansions within genes is associated with>30 neurological diseases. Of interest, (GGGGCC)>30-repeats within C9orf72 are associated with amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). These expansions can be 100s to 1000s of units long. Thus, it is perplexing how RNA-polymerase II (RNAPII) can successfully transcribe them. Recent investigations focusing on GGGGCC-transcription have identified specific, canonical complexes that may promot...
Source: Trends in Genetics - Category: Genetics & Stem Cells Source Type: research
Unintentional injuries are the leading cause of disability and mortality in youth across the United States and globally. Attention-deficit hyperactivity disorder (ADHD) has been associated with an increased rate of unintentional injuries in multiple co...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: The Global Burden of Disease study has generated a wealth of data on death and disability in Europe. At a time of change for the European Union and European Region of WHO, with a new Health Commissioner and Regional Director, respectively, a re...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
Early diagnosis of Parkinson's diseases (PD) is challenging; applying machine learning (ML) models to gait characteristics may support the classification process. Comparing performance of ML models used in various studies can be problematic due to differen...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
This study (1) reports on the level of happiness among older adults in Singapore and (2) examines the potential m...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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os AC Abstract PURPOSE: To examine the effects of Arrabidaa chica (Bignoniacea) extract, a native plant of the Amazon known as crajiru, on a 7,12-dimethyl-1,2-benzanthracene (DMBA)-induced breast cancer model in Wistar rats. METHODS: We compared the response of breast cancer to the oral administration of A. chica extract (ACE) for 16 weeks, associated or not with vincristine. Groups: normal control; DMBA (50mg/kg v.o,) without treatment; DMBA+ACE (300 mg/kg); DMBA+vincristine. 500μg/kg injected i.p; DMBA+ACE+Vincristine 250μg/kg i.p. Imaging by microPET and fluorescence, biochemistry, oxidative stress, ...
Source: Acta Cirurgica Brasileira - Category: Surgery Authors: Tags: Acta Cir Bras Source Type: research
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This study was carried out to test whether swimming training and grape seed proanthocyanidin extract (GSPE) are suitable interventions for curtailing free radical generation in the dmPFC in middle-aged male rats. The results indicated that superoxide and hydrogen peroxide increased in the middle-aged, as did lipid and protein oxidations, while superoxide dismutase and catalase activity decreased. There were positive correlations between age and lipofuscin. Importantly, the rats experienced reductions in neuronal number, volume and density in the dmPFC. Rats under combined interventions displayed more alleviation of the age...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
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