Improved rabies vaccine could be better and cheaper

An estimated 60,000 people die of rabies each year, in part because of the lack of access to a cheap and simple vaccine – a new version could change that
Source: New Scientist - Health - Category: Consumer Health News Source Type: research

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In conclusion, our results demonstrate that MPLA serving as an adjuvant enhances the intensity of humoral immune responses by activating the cDC–Tfh–GC B axis. Our findings will contribute to the improvement of the efficiency of traditional rabies vaccines.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
by Bruce A. Kimball, Steven F. Volker, Doreen L. Griffin, Shylo R. Johnson, Amy T. Gilbert Rabies is a zoonotic disease caused by infection with rabies virus, which circulates naturally in several wild carnivore and bat reservoirs in the United States (US). The most important reservoir in the US from an animal and public health perspective is the raccoon (Procyon lotor). To prevent the westward expansion of a significant raccoon rabies epizootic along the eastern seaboard, an operational control program implementing oral rabies vaccination (ORV) has existed in the US since the 1990s. Recently, two vaccine efficacy studies...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
ConclusionsWithout strong surveillance systems, rabies-free countries are vulnerable to becoming endemic when incursions happen. To prevent this, it may be necessary to vaccinate at least 38% to 56% of the susceptible dog population depending on the risk of reintroduction and transmission dynamics.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
World-leading vaccine scientists from the University of Bristol are working with one of Vietnam's major vaccine manufacturers, Vabiotech, to share cutting-edge knowledge that could help prevent future global outbreaks of avian flu and rabies.
Source: University of Bristol news - Category: Universities & Medical Training Tags: Health, International, Research; Faculty of Life Sciences, Faculty of Life Sciences, School of Biochemistry, Institutes, Institutes, Bristol BioDesign Institute; Press Release Source Type: news
Publication date: 23 November 2019Source: New Scientist, Volume 244, Issue 3257Author(s): Ruby Prosser Scully
Source: New Scientist - Category: Science Source Type: research
Rabies is estimated to cause 59,000 deaths and economic losses of US$8.6 billion every year. Despite several years of rabies surveillance and awareness programmes, increased availability of post-exposure proph...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
AbstractDog demographics are considered as one of the main factors in the control of rabies. Having reliable data on dog population and husbandry practices on how they are managed is a key point in the elaboration of any control program to fight against human deaths due to rabies which are mainly due to dogs. However, the lack of data regarding dog population is one of the main hindrances to elaborate effective fighting projects in developing countries, particularly in Africa. In order to contribute for reliable data on dog demographics and husbandry practices related to rabies, this study was carried out in the cities of ...
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
New research raises hopes of oral vaccine for dogs, the chief source of transmission to humansResearchers have discovered a way to stop rabies from shutting down critical responses in the immune system, a breakthrough that could pave the way for new tools to fight the deadly disease.Rabies kills almost60,000 people each year, mostly affecting poor and rural communities.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Global health Infectious diseases Global development Science Medical research Vaccines and immunisation World news Source Type: news
Condition:   Rabies Interventions:   Biological: ChAdOx2 RabG;   Biological: Inactivated Rabies Vaccine Sponsor:   University of Oxford Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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