Wnt- β-catenin signaling pathway, the Achilles' heels of cancer multidrug resistance.
CONCLUSION: Wnt signaling has been involved in several pathophysiological states, including carcinogenesis and embryonic development. Wnt signaling is linked to various aspects of MDR including P-glycoprotein and multidrug resistance protein 1 regulation through its canonical and non-canonical pathways. Wnt/β-catenin signaling has also linked to other pathways such as NF-κB and PI3K-Akt involving cancer progression. Accordingly, Wnt/β-catenin signaling can be a potential target for cancer therapy.
PMID: 31721699 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Ghandadi M, Valadan R, Mohammadi H, Akhtari J, Khodashenas SA, Ashari S Tags: Curr Pharm Des Source Type: research
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