Wnt- β-catenin signaling pathway, the Achilles' heels of cancer multidrug resistance.

CONCLUSION: Wnt signaling has been involved in several pathophysiological states, including carcinogenesis and embryonic development. Wnt signaling is linked to various aspects of MDR including P-glycoprotein and multidrug resistance protein 1 regulation through its canonical and non-canonical pathways. Wnt/β-catenin signaling has also linked to other pathways such as NF-κB and PI3K-Akt involving cancer progression. Accordingly, Wnt/β-catenin signaling can be a potential target for cancer therapy. PMID: 31721699 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research