Distinct Disease Phenotype of Ulcerative Colitis in Patients With Coincident Primary Sclerosing Cholangitis: Evidence From a Large Retrospective Study With Matched Cohorts
This study aimed to assess the impact of primary sclerosing cholangitis on disease phenotype and its course in patients with ulcerative colitis.
DESIGN:
This is a retrospective study with 3:1 matched cohorts.
SETTINGS:
Tertiary care center’s electronic database was used for data analysis from 2000 and 2018.
PATIENTS:
Of 782 patients with ulcerative colitis, 77 patients who had coincident primary sclerosing cholangitis were included.
MAIN OUTCOME MEASURES:
The primary outcomes evaluated were disease characteristics including colonic disease activity, temporal change of disease course, colorectal neoplasia, and colectomy rates.
RESULTS:
Disease activity during acute flares, assessed by the complete Mayo score, was significantly lower in patients with primary sclerosing cholangitis (6.2 vs 7.3; p
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Inflammatory Bowel Disease Source Type: research
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