Age-related Hearing Loss Is Strongly Associated With Cognitive Decline Regardless of the APOE4 Polymorphism
Objective: To examine the association between hearing impairment and cognitive decline and to identify possible risk factors for presbycusis. Study Design: Cross-sectional survey in prospective cohort study. Setting: University hospital. Patients: A total of 322 participants aged>60 years, for whom all the below data were available, were enrolled in the study. There were 168 females and 154 males with a median age of 71 years (range: 60–89 yrs). Interventions: PROST (Project in Sado for Total Health), a medical database in Sado island Japan, was analyzed. Main Outcome Measures: Data on pure-tone audiometry, mini-mental state examination (MMSE), polymorphism of apolipoprotein E4 (ApoE4), diabetes mellitus, hypertension, smoking, and alcohol consumption were extracted. Hearing impairment was defined as an average frequency between 0.25 and 8 kHz that exceeded 30 dB. Multivariate analysis was used to identify which of the above factors could predict the hearing impairment. Hearing threshold of each Hz was compared between the ApoE4 (+/+), (+/−), and (−/−) groups. Results: Among various factors, only low MMSE scores (
Condition: Gestational Diabetes Interventions: Other: Meal A; Other: Meal B Sponsor: Massachusetts General Hospital Not yet recruiting
Conditions: Diabetic Macular Edema; Macular Edema; Type 2 Diabetes With Diabetic Macular Edema; Type 1 Diabetes With Diabetic Macular Edema; Diabetic Retinopathy Intervention: Drug: MS-553 Sponsors: Shenzhen MingSight Relin Pharmaceuticals Co., Ltd.; Fountain Medical Development Co., Ltd. Not yet recruiting
Condition: Diabetes Mellitus, With Complications Intervention: Procedure: INTRAVITREAL RANIBIZUMAB INJECTION Sponsor: Ain Shams University Completed
Abstract We previously found that daidzein decreased food intake in female rats. To understand the mechanism of anorectic action of dietary daidzein, it is necessary to determine distributions of daidzein and S-equol, a metabolite of intestinal bacterial conversion from daidzein, in the body. In the present study, we measured the concentrations of daidzein and S-equol in serum and bile in sham-operated and ovariectomized female rats fed a diet containing 150 mg/kg daidzein for 7 days. Dietary daidzein increased serum and bile concentrations of S-equol to far higher levels than those of daidzein. S-equol concentrat...
In this study, we developed an ulnar-musculocutaneous nerve-transfer model wherein the biceps muscle of a mouse was re-innervated using a donor ulnar nerve. Similar muscle action potentials were detected in both the end-to-end suture of the transected nerve (correctrepair) group and the ulnar-musculocutaneous nerve-transfer group. Also, re-innervated acetylcholine receptor (AChR) clusters and muscle spindles were observed in both procedures. There were fewer re-innervated AChR clusters in the nerve transfer group than in the correct repair group at 4 weeks, but the numbers were equal at 24 weeks following surgery. Thus, ou...
Abstract Unilateral training of both lateral limbs increases unilateral muscle strength, whereas bilateral training increases bilateral muscle strength, a phenomenon known as lateral specificity in resistance training. Although motor imagery (MI) combined with action observation (AO) (i.e., MI + AO) training increases muscle strength, it is not completely understood whether such training increases the lateral specificity of muscle strength in a way resistance training does. To investigate whether MI + AO induces lateral specificity of muscle strength increase, 18 healthy subjects were divided into groups: MI + AO ...
Limiting food consumption to a 10-hour window a day, so-called time-restricted eating, promotes weight loss and improves lipids/blood pressure in patients with metabolic syndrome.Medscape Medical News
A woman who presented with an atypical proximal tibial stress fracture was consequently diagnosed with hypophosphatasia. Did bisphosphonate use play a role in this case?Journal of the Endocrine Society
Combined pasireotide and pegvisomant treatment may offer another approach for patients with acromegaly resistant to other treatment options.Journal of Clinical Endocrinology &Metabolism