Age-related Hearing Loss Is Strongly Associated With Cognitive Decline Regardless of the APOE4 Polymorphism

Objective: To examine the association between hearing impairment and cognitive decline and to identify possible risk factors for presbycusis. Study Design: Cross-sectional survey in prospective cohort study. Setting: University hospital. Patients: A total of 322 participants aged>60 years, for whom all the below data were available, were enrolled in the study. There were 168 females and 154 males with a median age of 71 years (range: 60–89 yrs). Interventions: PROST (Project in Sado for Total Health), a medical database in Sado island Japan, was analyzed. Main Outcome Measures: Data on pure-tone audiometry, mini-mental state examination (MMSE), polymorphism of apolipoprotein E4 (ApoE4), diabetes mellitus, hypertension, smoking, and alcohol consumption were extracted. Hearing impairment was defined as an average frequency between 0.25 and 8 kHz that exceeded 30 dB. Multivariate analysis was used to identify which of the above factors could predict the hearing impairment. Hearing threshold of each Hz was compared between the ApoE4 (+/+), (+/−), and (−/−) groups. Results: Among various factors, only low MMSE scores (
Source: Otology and Neurotology - Category: ENT & OMF Tags: SENSORINEURAL HEARING LOSS AND TINNITUS Source Type: research

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Authors: Lin L, Xu X, Yu Y, Ye H, He X, Chen S, Chen X, Shao Z, Chen P Abstract Objective: There were some clinical studies on GLP-1R agonist liraglutide therapy for psoriasis patients with type 2 diabetes, but there is a lack of randomized controlled trials and the mechanism of which remains unclear.Method: A total of 25 psoriasis patients with type 2 diabetes were randomized 1: 1 divided into the control group (n = 13) or liraglutide group (n = 12) for 12 weeks. We determined the PASI, the DLQI, histopathology of psoriasis skin, and the expression of IL-17, IL-23, and TNF-α in th...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
CONCLUSIONS: The validity of ICD-10 codes for cirrhosis, oesophageal varices and HCC is high. However, coding for ascites should be combined with a code of chronic liver disease to have an acceptable validity. PMID: 32960654 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
[A REPORT ON 2017 NATIONWIDE SURVEY OF IMMEDIATE TYPE FOOD ALLERGIES IN JAPAN (SUPPORTED BY A GRANT FROM "CONSUMER AFFAIRS AGENCY, GOVERNMENT OF JAPAN")]. Arerugi. 2020;69(8):701-705 Authors: Imai T, Sugizaki C, Ebisawa M PMID: 32963194 [PubMed - as supplied by publisher]
Source: Arerugi - Category: Allergy & Immunology Authors: Tags: Arerugi Source Type: research
Abstract The case involved a man in his forties. While working at the restaurant that the patient runs, the patient experienced a stab-like pain on the left shoulder and developed systemic pruritic eruptions. He was diagnosed with anaphylaxis upon visiting our emergency department. Conjunctival hyperemia, lip swelling, cold sweats, and nausea presented later. A cap fluorescence enzyme immunoassay using the serum of the patient showed specific immunoglobulin E (IgE) positivity for wasps; therefore, we hypothesized that he had anaphylaxis caused by the insect's sting. Insects of the same species as that by which the...
Source: Arerugi - Category: Allergy & Immunology Authors: Tags: Arerugi Source Type: research
CONCLUSION: We diagnosed the patient with allergic contact dermatitis due to the EITC and BITC present in nitrile rubber gloves, and considered that alkyl isothiocyanate might also have played a causative role. We propose that nitrile rubber gloves should be produced without using vulcanization accelerators. PMID: 32963190 [PubMed - as supplied by publisher]
Source: Arerugi - Category: Allergy & Immunology Authors: Tags: Arerugi Source Type: research
This article addresses the Evaluation of Ertugliflozin Efficacy and Safety Cardiovascular Outcomes (VERTIS-CV) trial, its background, design, results, and implications. In patients at least 40 years of age with atherosclerotic cardiovascular disease (ASCVD), the VERTIS-CV trial demonstrated ertugliflozin was non-inferior to placebo for major adverse cardiovascular events, though not superior. Ertugliflozin significantly reduced hospitalization for heart failure compared to placebo. The composite renal outcome was not significantly different between groups. Ertugliflozin was generally well tolerated with a safety profi...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
After significant APA advocacy, the House Veterans ’ Affairs Committee removed a proposal to implement a pilot program allowing clinical psychologists to prescribe and manage medications for veterans who seek care in the Veterans Health Administration.After learning about the proposal, APA issued an advocacy alert that resulted in over 1,000 members sending more than 3,000 letters to their elected officials on Capitol Hill, opposing the proposal and urging lawmakers to ensure veterans receive the highest quality mental health care possible. Similarly, APA leadership, as well as government relations and policy staff m...
Source: Psychiatr News - Category: Psychiatry Tags: advocacy APA lobbying psychologists prescribing Saul Levin VA veterans Source Type: research
This report describes that the prevalences of prepregnancy obesity and gestational diabetes were higher among pregnant women hospitalized for COVID-19-related illness than among those admitted for pregnancy-related treatment or procedures and found to have COVID-19.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Diabetes MMWR Morbidity & Mortality Weekly Report Pregnancy COVID-19 Coronavirus Disease 2019 Source Type: news
Conclusions. Human islet isolates with insufficient beta-cell mass for implantation within 72 hours can be cultured for 96 hours and longer to combine multiple preparations in order to reach the desired beta-cell dose and therefore result in a better metabolic benefit.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Conclusions. BAT remarkably enhances the viability and biological function of the transplanted ectopic islets. Moreover, the anatomical location of BAT lends itself to biopsy, removal, and islet retransplantation, which strongly suggests the BAT as a potential desirable site for islet transplantation in basic and clinical research.
Source: Transplantation - Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
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