Adverse effects of TNF inhibitor in a patient with DiGeorge syndrome and juvenile idiopathic arthritis

DiGeorge syndrome (DGS) is the most common congenital chromosome deletion syndrome which appears in 1:4000 live births as the result of 22q11.2 microdeletion1. It is a primary immunodeficiency disease (PID), characterized with decreased T-cell numbers1,2. There is a growing body of evidence that DGS is associated with humoral immune deficiency (ID) as the result of B-lymphocyte functional deficit, leading to hypogammaglobulinemia1,2. Patients with DGS show increased incidence of infection and autoimmune diseases (ADs)1.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research

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CONCLUSION:: Carpal tunnel release under platelet inhibition with acetylsalicylic acid is safe and can be performed without interruption of such medication. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. PMID: 31985640 [PubMed - in process]
Source: Hand Surgery - Category: Surgery Authors: Tags: Plast Reconstr Surg Source Type: research
Publication date: Available online 28 January 2020Source: Best Practice &Research Clinical RheumatologyAuthor(s): Ana M. Ortiz, Sebnem Ataman
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 27 January 2020Source: Best Practice &Research Clinical RheumatologyAuthor(s): Peter C. Taylor, Shing T. LawAbstractThe outlook for people living with rheumatoid arthritis (RA) has improved tremendously in a generation. Major contributions to this include recognition of the importance of early treatment initiation, improved understanding of the pathobiology, the identification of therapeutic targets and their subsequent validation in clinic trials and the realisation of the importance of ‘tight control’ of inflammatory responses. Despite these advances, many patients meeti...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 27 January 2020Source: Best Practice &Research Clinical RheumatologyAuthor(s): Lykke Midtbøll Ørnbjerg, Mikkel ØstergaardAbstractStructural damage progression in patients with established rheumatoid arthritis (RA) has traditionally been assessed by conventional radiography (CR), which has proven its value in clinical practice and clinical trials over the past decades. The most prominent abnormalities visualized by CR in RA patients are erosions as a consequence of bone destruction and joint space narrowing (JSN) as a consequence of cartilage damage. Several valida...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 27 January 2020Source: Best Practice &Research Clinical RheumatologyAuthor(s): Serena Bugatti, Emanuele Bozzalla Cassione, Ludovico De Stefano, Antonio ManzoAbstractThe development of rheumatoid arthritis (RA), at least in its autoantibody-positive subset, evolves through a series of events starting well before the appearance of synovitis. The distinction between ‘early’ and ‘established’ RA is, therefore, an evolving concept. In routine practice, however, the management of RA still starts with the occurrence of clinically detectable synovitis. As such, the syn...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 28 January 2020Source: Respiratory Medicine Case ReportsAuthor(s): Silvia De Rosa, Gianlorenzo Golino, Claudio RoncoAbstractStatus asthmaticus is a life-threatening disorder that can manifest in dangerous levels of hypercapnia and acidosis. The use of extracorporeal carbon dioxide removal (ECCO2R) has been used successfully to control pH and PaCO2 in patients with acute severe asthma. The present report describes the use of this technology in near-fatal asthma with brain death, and awaiting organ harvest.The ProLUNG® system consists of a veno-venous hemoperfusion circuit with an artif...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
In conclusion, this study identified PAE and TLT as the main BACs of WTD in alleviating the severity of RA, and also developed a novel combination of PAE and TLT as a promising candidate drug for RA therapy.Graphical abstract
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 28 January 2020Source: Journal of EthnopharmacologyAuthor(s): Yu Wang, Yan-Jiao Chen, Cheng Xiang, Guang-Wei Jiang, Yu-Dong Xu, Lei-Miao Yin, Dong-Dong Zhou, Yan-Yan Liu, Yong-Qing YangAbstractEthnopharmacological relevanceStandard therapy for asthma, a highly heterogeneous disease, is primarily based on bronchodilators and immunosuppressive drugs, which confer short-term symptomatic relief but not a cure. It is difficult to discover novel bronchodilators, although potential new targets are emerging. Traditional Chinese Medicine (TCM) formulas have been used to treat asthma for more than ...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, TGP treatment ameliorates AIH by regulating hepatocyte apoptosis and DC maturation. TGP is a potential compound for AIH treatment.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
BY JESSICA DAMASSA BioLum Sciences is introducing new chemistry that has the potential to completely change the way we test for respiratory illnesses, like asthma, and analyze blood samples to identify hypertension. CEO Edward Allegra talks through the science behind both their breath and blood tests, both of which are patent-pending and have the ability to completely bend the cost-curve when it comes to identifying and monitoring these two common chronic conditions. What’s next for the early-stage health startup? A range of applications to detect everything from COPD to lung cancer and more. Filmed at Bayer G...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Tech Jessica DaMassa WTF Health Asthma Bayer G4A Bayer G4A Signing Day BioLum BioLum Sciences Edward Allegra Hypertension Source Type: blogs
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