Adverse effects of TNF inhibitor in a patient with DiGeorge syndrome and juvenile idiopathic arthritis
DiGeorge syndrome (DGS) is the most common congenital chromosome deletion syndrome which appears in 1:4000 live births as the result of 22q11.2 microdeletion1. It is a primary immunodeficiency disease (PID), characterized with decreased T-cell numbers1,2. There is a growing body of evidence that DGS is associated with humoral immune deficiency (ID) as the result of B-lymphocyte functional deficit, leading to hypogammaglobulinemia1,2. Patients with DGS show increased incidence of infection and autoimmune diseases (ADs)1.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Mario Sestan, Nastasia Kifer, Marijan Frkovic, Ana-Marija Laskarin, Marija Jelusic Tags: Letters Source Type: research
More News: Allergy | Allergy & Immunology | Arthritis | Asthma | Autoimmune Disease | Microdeletion Syndromes | Primary Immunodeficiency Disease | Rheumatology