Compulsory admissions and preferences in decision-making in patients with psychotic and bipolar disorders

ConclusionsPatients who experienced a different level of participation in decision-making than desired more frequently had compulsory admissions. We propose to assess participation preferences each time a relevant treatment decision is about to be made and tailor care accordingly. We identified several factors leading to compulsory admissions that can be modified to prevent further coercive measures.
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research

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Functional coupling of M1 muscarinic acetylcholine receptor to Gαq/11 in dorsolateral prefrontal cortex from patients with psychiatric disorders: a postmortem study. Eur Arch Psychiatry Clin Neurosci. 2019 Dec 05;: Authors: Odagaki Y, Kinoshita M, Meana JJ, Callado LF, García-Sevilla JA Abstract Accumulating studies have implicated intracellular signaling through muscarinic acetylcholine receptors (mAChRs) in psychiatric illness. In the present study, carbamylcholine chloride (carbachol)-induced Gαi/o and Gαq/11 activation was identified in postmortem human prefrontal cortical ...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
ConclusionsRumination is known to be associated with poor prognosis in mental health. This study suggests that rumination is a maladaptive coping style associated not only with worry, distress and illness severity, but also with socioeconomic status. Also, rumination demonstrated a specific association with panic disorder.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: Available online 7 December 2019Source: Progress in NeurobiologyAuthor(s): M.M.J. van den Berg, J. Krauskopf, J.G. Ramaekers, J.C.S. Kleinjans, J. Prickaerts, J.J. BriedéAbstractCirculating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as promising biomarkers for central nervous system (CNS) disorders because they are actively secreted as messengers and are profoundly involved in fine-tuning of developmental and differentiation processes. Furthermore, they are attractive biomarkers becau...
Source: Progress in Neurobiology - Category: Neuroscience Source Type: research
AbstractMajor psychiatric traits are genetically inter-correlated with one another, but it not well known which genes play pleiotropic effects across different traits. We curated and compared genes identified from large-scale genome-wide association studies for seven psychiatric traits, including depression, bipolar disorder, schizophrenia, autism spectrum disorder, attention-deficit/hyperactivity disorder, anxiety and neuroticism. We then explored biological functions of the top pleiotropic genes. A total of 243 cross-trait genes were identified for the seven traits. Except for autism spectrum disorder, there was signific...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
Almost half (48%) of children and adolescents with a psychotic disorder said they recently had suicidal thoughts or had in the past considered death by suicide when interviewed in the emergency department (ED) using a brief screening questionnaire, according to areport published this week inPsychiatric Services. Most of these youth did not report a chief complaint related to suicidal ideation or behavior when arriving at the ED.Notably, half of the children and adolescents who screened positive for suicide using the Ask Suicide-Screening Questions (ASQ) screen were discharged from the ED, including 44% of those who reporte...
Source: Psychiatr News - Category: Psychiatry Tags: Ask Suicide-Screening Questions Jonathan DeVylder Psychiatric Services psychotic disorders youth Source Type: research
Publication date: Available online 5 December 2019Source: Neuroscience LettersAuthor(s): Md Razib Hossain, Mostofa Jamal, Yu Tanoue, Daiki Ojima, Hiroo Takahashi, Takashi Kubota, Tuba M. Ansary, Asuka Ito, Naoko Tanaka, Hiroshi Kinoshita, Yasushi Kishimoto, Tohru YamamotoAbstractMDGA1 (MAM domain-containing glycosylphosphatidylinositol anchor) has recently been linked to schizophrenia and bipolar disorder. Dysregulation of dopamine (DA) and serotonin (5-HT) systems has long been associated with schizophrenia and other neuropsychiatric disorders. Here, we measured prepulse inhibition (PPI) of the startle response and ex viv...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 5 December 2019Source: NeuronAuthor(s): Sehyoun Yoon, Euan Parnell, Maria Kasherman, Marc P. Forrest, Kristoffer Myczek, Susitha Premarathne, Michelle C. Sanchez Vega, Michael Piper, Thomas H.J. Burne, Lachlan A. Jolly, Stephen A. Wood, Peter PenzesSummaryVariants in the ANK3 gene encoding ankyrin-G are associated with neurodevelopmental disorders, including intellectual disability, autism, schizophrenia, and bipolar disorder. However, no upstream regulators of ankyrin-G at synapses are known. Here, we show that ankyrin-G interacts with Usp9X, a neurodevelopmental-disorder-assoc...
Source: Neuron - Category: Neuroscience Source Type: research
Authors: Pershad Y, Guo M, Altman RB Abstract One in five Americans experience mental illness, and roughly 75% of psychiatric prescriptions do not successfully treat the patient's condition. Extensive evidence implicates genetic factors and signaling disruption in the pathophysiology of these diseases. Changes in transcription often underlie this molecular pathway dysregulation; individual patient transcriptional data can improve the efficacy of diagnosis and treatment. Recent large-scale genomic studies have uncovered shared genetic modules across multiple psychiatric disorders - providing an opportunity for an in...
Source: Pacific Symposium on Biocomputing - Category: Bioinformatics Tags: Pac Symp Biocomput Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Family General Holiday Coping Interview LifeHelper Podcast Relationships Stress The Psych Central Show Source Type: blogs
by Tyler Buddell, Vladislav Friedman, Cody J. Drozd, Christopher C. Quinn Common and rare variants of theCACNA1C voltage-gated calcium channel gene have been associated with autism and other neurodevelopmental disorders including schizophrenia, bipolar disorder and ADHD. However, little is known about howCACNA1C variants affect cellular processes to alter neurodevelopment. The Timothy syndrome mutation is a rarede novo gain-of-function variant inCACNA1C that causes autism with high penetrance, providing a powerful avenue into investigating the role ofCACNA1C variants in neurodevelopmental disorders. Here, we useegl-19, th...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
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