The First Acanthamoeba keratitis Case of Non-Contact Lens Wearer with HIV Infection in Thailand.

The First Acanthamoeba keratitis Case of Non-Contact Lens Wearer with HIV Infection in Thailand. Korean J Parasitol. 2019 Oct;57(5):505-511 Authors: Tananuvat N, Techajongjintana N, Somboon P, Wannasan A Abstract Acanthamoeba keratitis (AK) is a rare sight-threatening corneal infection, often reporting from contact lens wearers. An asymptomatic human immunodeficiency virus (HIV)-infected Thai male without history of contact lens use complained foreign body sensation at his left eye during motorbike riding. He had neither specific keratitis symptoms nor common drugs responding, which contributed to delayed diagnosis. By corneal re-scraping, Acanthamoeba-like cysts were detected by calcofluor white staining and agar culture. The etiological agent obtained from the culture was molecularly confirmed by Acanthamoeba spp.-specific PCR, followed by DNA sequencing. The results from BLAST and phylogenetic analysis based on the DNA sequences, revealed that the pathogen was Acanthamoeba T4, the major genotype most frequently reported from clinical isolates. The infection was successfully treated with polyhexamethylene biguanide resulting in corneal scar. This appears the first reported AK case from a non-contact lens wearer with HIV infection in Thailand. Although AK is sporadic in developing countries, a role of free-living Acanthamoeba as an opportunistic pathogen should not be neglected. The report would increase awareness of AK, especially in the case presenting...
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research

Related Links:

Purpose Microbial contamination of contact lens storage cases is associated with corneal disease ranging from sterile keratitis to sight threatening infections including bacterial and Acanthamoeba keratitis. Given the increasing association between water contact and contact lens-related disease, this study aimed to explore the effect of water contact and storage case contamination in habitual daily wear contact lens users.
Source: Contact Lens and Anterior Eye - Category: Opthalmology Authors: Source Type: research
[Acanthamoeba endophthalmitis-a case report]. Ophthalmologe. 2019 Nov 25;: Authors: Pascha J, Frings A, Walochnik J, Wissiak E, Dirisamer M, Daas L, Ardjomand N Abstract Diagnosis of acanthamoeba keratitis is often a clinical challenge. In most cases it is primarily confused with herpes keratitis. A coinfection with bacteria or fungi can also lead to a delayed diagnosis and initiation of treatment. A few cases reported the detection of acanthamoeba in the anterior chamber. In the case of endophthalmitis without the detection of bacteria or fungi acanthamoeba should therefore always be c...
Source: Der Ophthalmologe - Category: Opthalmology Authors: Tags: Ophthalmologe Source Type: research
Publication date: Available online 18 October 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Teck Boon Tew, Hsiao-Sang Chu, Yu-Chih Hou, Wei-Li Chen, I-Jong Wang, Fung-Rong HuPurposeTo study the surgical outcome of therapeutic penetrating keratoplasty (TPK) for medically uncontrolled microbial keratitis at a tertiary hospital in Taiwan over a 14-year period.MethodsThis is a retrospective case series study. Patients who underwent TPK at National Taiwan University Hospital in 2001–2014 were included. Patients were divided into 3 diagnostic groups: bacterial keratitis, fungal keratitis, and acanthamoe...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Abstract PURPOSE: To study the surgical outcome of therapeutic penetrating keratoplasty (TPK) for medically uncontrolled microbial keratitis at a tertiary hospital in Taiwan over a 14-year period. METHODS: This is a retrospective case series study. Patients who underwent TPK at National Taiwan University Hospital in 2001-2014 were included. Patients were divided into 3 diagnostic groups: bacterial keratitis, fungal keratitis, and acanthamoeba keratitis. Each of the following criteria was evaluated: graft clarity at 1 month and 1 year postoperatively, cure of the disease, and anatomical success rate. RESU...
Source: J Formos Med Assoc - Category: General Medicine Authors: Tags: J Formos Med Assoc Source Type: research
This patient with recurrent unilateral ocular complaints, a lid lesion, and keratitis unresponsive to numerous medications as well as a negative work-up for infectious agents leaves us with numerous diagnostic possibilities. These include: viral shedding from the lid lesion as with molluscum, eyelid deformity with corneal exposure, limbal stem cell deficiency of uncertain etiology, ocular surface dysplasia or neoplasia, superior limbic keratoconjunctivitis, vernal keratoconjunctivitis, herpes group viruses, Acanthamoeba keratitis, eyelid foreign body, medicamentosa, and many others.
Source: Journal of Cataract and Refractive Surgery - Category: Opthalmology Authors: Tags: Consultation section: Cataract Source Type: research
Eye, Published online: 25 September 2019; doi:10.1038/s41433-019-0589-6Acanthamoeba keratitis in Australia: demographics, associated factors, presentation and outcomes: a 15-year case review
Source: Eye - Category: Opthalmology Authors: Source Type: research
To report the clinical and microbiological features of Acanthamoeba keratitis (AK) related to contact lens use in a tertiary hospital in China.
Source: BMC Ophthalmology - Category: Opthalmology Authors: Tags: Research article Source Type: research
Conclusions: In an in vitro assay, voriconazole reduced the cysticidal activity of 2 commonly used antiamoebic drugs. Although the in vivo drug interactions could be different, these observations may be useful in cases of nonhealing Acanthamoeba keratitis being treated with combination therapies that include voriconazole.
Source: Cornea - Category: Opthalmology Tags: Basic Investigation Source Type: research
CONCLUSION: PHMB 0.02% monotherapy for the initial treatment of AK is as effective as biguanide+diamidine combination therapy. Chlorhexidine monotherapy was too infrequent for comparison. The outcome data are the most detailed available. PMID: 31401556 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
New England Journal of Medicine,Volume 381, Issue 3, Page 274-274, July 2019.
Source: New England Journal of Medicine - Category: Internal Medicine Authors: Source Type: research
More News: Acanthamoeba Keratitis | Antibiotic Therapy | Eyes | Free Living Amoebozoa Infection | Parasitology | Thailand Health