Deletion of Smad3 prevents renal fibrosis and inflammation in type 2 diabetic nephropathy

Transforming growth factor (TGF)- β/Smad3 signaling is highly activated in kidneys of patients with type 2 diabetic nephropathy (T2DN), however, the precise role of Smad3 in the pathogenesis of diabetic nephropathy remains unclear.

Source: Metabolism - Clinical and Experimental - November 13, 2019 Category: Biomedical Science Authors: Bi-Hua Xu, Jingyi Sheng, Yong-Ke You, Xiao-Ru Huang, Ronald C.W. Ma, Qingwen Wang, Hui-Yao Lan Source Type: research