Genetic deletion of a short fragment of glucokinase in rabbit by CRISPR/Cas9 leading to hyperglycemia and other typical features seen in MODY-2.

In conclusion, this novel GCK mutant rabbit generated with the CRISPR/Cas9 system mimics most, if not all, histopathological and functional defects seen in MODY-2 patients such as hyperglycemia and will be a valuable rabbit model for preclinical studies and drug screening for diabetes as well as for studying the pathophysiological role of glucokinase. PMID: 31720743 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31720743?dopt=Abstract

Source: Cellular and Molecular Life Sciences : CMLS - November 12, 2019 Category: Cytology Authors: Song Y, Sui T, Zhang Y, Wang Y, Chen M, Deng J, Chai Z, Lai L, Li Z Tags: Cell Mol Life Sci Source Type: research