Ionic liquid functionalized biogenic synthesis of AgAu bimetal doped CeO2 nanoparticles from Justicia adhatoda for pharmaceutical applications: Antibacterial and anti-cancer activities

Publication date: Available online 13 November 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Pandiyan Nithya, Murugesan Balaji, Arumugam Mayakrishnan, Chinnalagu Dhilip Kumar, Selvaraj Rajesh, Azhagar Surya, Mahalingam SundrarajanAbstractThe noble metal such as Ag and Au doped CeO2 nanoparticles was successfully prepared by ionic liquid assisted hydrothermal method in the presence of Justicia adhatoda leaves extract and were used as an antibacterial and anticancer agent. The FT-IR and Raman spectrum exhibit the peaks at 460 and 464 cm−1 assigned to CeO stretching vibrations of NPs. The electron microscopic micrographs confirmed the spherical shaped morphology of prepared NPs. The insertion of Ag and Au ions into the CeO2 surface creates lattice defects the leads to reduce the band gap energy of Ag-Au/CeO2 at 3.15 eV. The XRD results suggested the average crystalline size of the silver‑gold loaded CeO2 was 28 nm. From the elemental mapping images, we have visualized that existence and uniform distribution of Ag, Au, Ce, and O in the prepared nanomaterials. The antibacterial activity of unloaded and bimetal loaded CeO2 NPs was evaluated with Gram-positive and Gram-negative bacteria using disc diffusion assay. The AgAu loaded CeO2 NPs exhibited the highest zone of inhibition against E. coli and S. aureus strains when compared with pristine CeO2, Ag loaded CeO2, and Au loaded CeO2 NPs. In addition, the 100 μg mL−1 of CeO2, ...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research

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Publication date: Available online 9 December 2019Source: Journal of ColoproctologyAuthor(s): Seyedeh Elham Norollahi, Seyed Mohammad Taghi Hamidian, Zeynab Khazaee Kohpar, Rezvan Azadi, Pooya Rostami, Sogand Vahidi, Sahar Ghazanfari, Farnaz Azar Shabe, Roya Khaksar, Ali Akbar SamadaniAbstractColorectal cancer is one of the most important malignancies in the classification of gastrointestinal cancers. One of the predisposing factors at molecular level for this cancer is via WNT signaling which is associated with the vast numbers of different genes. Thus, in this study, we aimed to investigate whether Adenomatous Polyposis ...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
Authors: Kawanishi M, Hisatomi Y, Oda Y, Shimohara C, Tsunematsu Y, Sato M, Hirayama Y, Miyoshi N, Iwashita Y, Yoshikawa Y, Sugimura H, Mutoh M, Ishikawa H, Wakabayashi K, Yagi T, Watanabe K Abstract Colibactin is a polyketide-peptide genotoxin produced by enteric bacteria such as E. coli, and is considered to contribute to the development of colorectal cancer. We previously isolated E. coli strains from Japanese colorectal cancer patients, and in the present study we investigated the genotoxic potency of the colibactin-producing (clb+) E. coli strains that carry the polyketide synthases "pks" gene cluste...
Source: Journal of Toxicological Sciences - Category: Toxicology Tags: J Toxicol Sci Source Type: research
Six new dihydroisocoumarins, aspergimarins A−F (1−6), were discovered together with five known analogs (7−11) from a monoculture of the sponge-derived fungus Aspergillus sp. NBUF87. The structures of these compounds were elucidated through comprehensive spectroscopic methods, and absolute configurations were assigned after X-ray crystallography, use of the modified Mosher’s method, and comparison of electronic circular dichroism (ECD) data with literature values for previously reported analogs. Compounds 1−11 were evaluated in a variety of bioassays, and at 100 μM, both 1 and 5 showed signi...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Authors: Nekrasov KA, Vikarchuk MV, Rudenko EE, Ivanitskiy IV, Grygorenko VM, Danylets RO, Kondratov AG, Stoliar LA, Sharopov BR, Kashuba VI Abstract The detection of prostate cancer (PCa) biomarkers in bodily fluids, a process known as liquid biopsy, is a promising approach and particularly beneficial when performed in urine samples due to their maximal non-invasiveness requirement of collection. A number of gene panels proposed for this purpose have allowed discrimination between disease-free prostate and PCa; however, they bear no significant prognostic value. With the purpose to develop a gene panel for PCa dia...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
The host-defense peptide (HDP) piscidin 1 (P1), isolated from the mast cells of striped bass, has potent activities against bacteria, viruses, fungi, and cancer cells and can also modulate the activity of membrane receptors. Given its broad pharmacological potential, here we used several approaches to better understand its interactions with multicomponent bilayers representing models of bacterial (phosphatidylethanolamine (PE)/phosphatidylglycerol) and mammalian (phosphatidylcholine/cholesterol (PC/Chol)) membranes. Using solid-state NMR, we solved the structure of P1 bound to PC/Chol and compared it with that of P3, a les...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Membrane Biology Source Type: research
By SAURABH JHA, MD Slumdog TB No one knows who gave Rahul Roy tuberculosis. Roy’s charmed life as a successful trader involved traveling in his Mercedes C class between his apartment on the plush Nepean Sea Road in South Mumbai and offices in Bombay Stock Exchange. He cared little for Mumbai’s weather. He seldom rolled down his car windows – his ambient atmosphere, optimized for his comfort, rarely changed. Historically TB, or “consumption” as it was known, was a Bohemian malady; the chronic suffering produced a rhapsody which produced fine art. TB was fashionable in Victorian Britain...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Artificial Intelligence Health Tech Saurabh Jha TB tuberculosis Source Type: blogs
Publication date: 15 February 2020Source: Materials Chemistry and Physics, Volume 242Author(s): A.S. Rajashekharaiah, G.P. Darshan, H.B. Premkumar, P. Lalitha, S.C. Sharma, H. NagabhushanaAbstractNano biotechnology is rapidly growing eco-friendly research area and used in various broad sections, such as biology, chemistry, physics, biomedicine and material engineering. The synthesis of highly efficient, non-toxic, inexpensive and environmental friendly nanomaterial is an urgent need. The aim of the present work was assessment of anti-oxidant, anti-bacterial and cytotoxicity potentials of Bi2Zr2O7:Dy3+ (1–11 mol ...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Abstract D-Allose is a rare sugar, can be used as an ingredient in a range of foods and dietary supplements, has alimentary activities, especially excellent anti-cancer effects and used in assisting cancer chemotherapy and radiotherapy, etc. To develop a simple and low-cost process for D-allose production, a one-pot enzymatic process using the substrate of D-fructose, and the recombinant enzymes of D-psicose 3-epimerase (DPE) and L-rhamnose isomerase (L-RhI) was developed. These enzymes were cloned from Ruminococcus sp. and B. subtilis, respectively, successfully expressed in E. coli, extracted and immobilized usi...
Source: Bioprocess and Biosystems Engineering - Category: Biomedical Engineering Authors: Tags: Bioprocess Biosyst Eng Source Type: research
AbstractOf all genetic mutations causing human disease, premature termination codons (PTCs) that result from splicing defaults, insertions, deletions, and point mutations comprise around 30%. From these mutations, around 11% are a substitution of a single nucleotide that change a codon into a premature termination codon. These types of mutations affect several million patients suffering from a large variety of genetic diseases, ranging from relatively common inheritable cancer syndromes to muscular dystrophy or very rare neuro-metabolic disorders. Over the past three decades, genetic and biochemical studies have revealed t...
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research
CONCLUSION: All the three methods have high accuracy for the diagnosis of H. pylori infection in the Vietnamese population with gastritis and gastric ulcers. These tests can be employed in the clinical settings for the Vietnamese population. CLO test should be used in combination with the other tests to reduce false-negative results. PMID: 31759377 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
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