Gold nanoparticles synthesized from Euphorbia fischeriana root by green route method alleviates the isoprenaline hydrochloride induced myocardial infarction in rats

In this study, the retrieving of gold nanoparticles from Euphorbia fischeriana root was amalgamated by standard procedure. Fabricated gold nanoparticles were portrayed through the investigations of ultraviolet and visible spectrophotometry (UV–Vis), Fourier transform infrared spectroscopy (FTIR), High resolution transmission electron microscopy (HRTEM) and X-ray diffraction (XRD). The UV–Vis and FTIR results explicated the obtained particles were sphere-shaped and the terpenoids of Euphorbia fischeriana had strong communications with gold surface. The HRTEM and XRD images exposed the produced gold nanoparticles had an extreme composition of crystal arrangement and excellent uniformed size of particles. In our study, the Isoprenaline induced myocardial damage established the elevation in TBARS, LOOH of heart tissues and notable decline in antioxidant enzymes SOD, CAT, GPx, and GSH. This biochemical result was additionally proved by histopathological assessment. Remarkably, the pretreatment with EF-AuNps(50 mg/kg b.w) illustrated stabilized levels of serum creatine and cardiotropins in myocardial infarcted animals. And further we understood the essential function of NF-ƙB, TNF-α, IL-6 signaling molecules and its way progression in the development of vascular tenderness.
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research

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Diagnostic accuracy of troponin T measured ≥6h after symptom onset for ruling out myocardial infarction. Scand Cardiovasc J. 2019 Dec 09;:1-9 Authors: Khoshnood A, Erlandsson M, Isma N, Yndigegn T, Mokhtari A Abstract Objectives: Guidelines recommend a single high-sensitivity cardiac troponin T (hs-cTnT) ≤14 ng/L measured ≥6 h after chest pain onset combined with a GRACE score
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
In new research, low-dose aspirin -- or amounts ranging from 75 to 150 milligrams -- was not found to reduce the risk for heart attack among African-American adults.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Abstract The close connection and interaction between the cardiac and the liver functions are well-known, as cirrhotic cardiomyopathy is an important clinical entity which best describes the mutual pathogenical influence between these two organs. Due to the fact that cardiac dysfunction in patients with chronic hepatic disorders is oligosymptomatic or even asymptomatic, an early diagnosis represents a challenge for every physician. Syndecan-1-a transmembrane proteoglycan that exerts its functions mainly via its heparane sulfate chains-is a very promising biomarker, correlated not only with the degree of cardiac fi...
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
We report a case of Kounis syndrome type III (coronary thrombosis) variant in a 48-year-old male, who had suffered recurrent acute myocardial infarction after scallion-induced hypersensitivity reactions. Following appropriate anti-thrombotic, anti-histamine and reperfusion strategies, the patient was found to have elevated levels of IgE and chronic urticaria. Upon administration of omalizumab there was an improvement of chronic urticaria, decrease in IgE levels and abolishing of the ischemic attacks.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
(Natural News) Everybody needs proper rest to allow the mind and body to rejuvenate. While a good night’s sleep is important for overall health, it is particularly crucial for the health of a person’s heart. Recent evidence suggests that inadequate sleep could lead to heart problems. A study published in the journal Psychosomatic Medicine found that...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
TUESDAY, Dec. 10, 2019 -- Heavy pot users are nearly two times more likely to have a heart attack after common types of surgeries as those who don't use the drug, a new study shows. " While cannabis is often purported as being safe or benign, we...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Authors: Pan RY, Zhao CH, Yuan JX, Zhang YJ, Jin JL, Gu MF, Mao ZY, Sun HJ, Jia QW, Ji MY, Zhang J, Wang LS, Ma WZ, Ma WQ, Ding JD, Jia EZ Abstract Circular RNAs (circRNAs) are potential biomarkers and therapeutic targets of coronary artery disease due to their high stability, covalently closed structure. And implied roles in gene regulation. The aim of this study was to identify and characterize circRNAs from human coronary arteries. Epicardial coronary arteries were removed during the autopsy of an 81-year-old man who died from heart attack. The natural history and histological classification of atherosclerotic l...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
TUESDAY, Dec. 10, 2019 -- A newly developed model has good discriminatory ability for six-month post-acute myocardial infarction (AMI) mortality, according to a study published online Dec. 10 in the Annals of Internal Medicine. John A. Dodson, M.D.,...
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Title: AHA News: Public Enemy's Keith Shocklee Turns Heart Attack Into Call to ActionCategory: Health NewsCreated: 12/9/2019 12:00:00 AMLast Editorial Review: 12/10/2019 12:00:00 AM
Source: MedicineNet Heart General - Category: Cardiology Source Type: news
Background Diabetes mellitus predicts poorer outcomes in patients with acute coronary syndrome (ACS), but the magnitude of this association in patients at older ages remains controversial. Methods Data were extracted from the Codi Infart database. All consecutive patients with diagnosis of ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) between 2010 and 2015 were included. We assessed the impact of diabetes mellitus on 30-day and one-year mortality in patients aged less than and at least 75 years. Results A total of 12 792 cases were registered, of whom...
Source: Coronary Artery Disease - Category: Cardiology Tags: Myocardial Infarction/Cardiogenic Shock Source Type: research
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