Genes, Vol. 10, Pages 931: HisCoM-PAGE: Hierarchical Structural Component Models for Pathway Analysis of Gene Expression Data

Genes, Vol. 10, Pages 931: HisCoM-PAGE: Hierarchical Structural Component Models for Pathway Analysis of Gene Expression Data Genes doi: 10.3390/genes10110931 Authors: Mok Kim Lee Choi Lee Jang Park Although there have been several analyses for identifying cancer-associated pathways, based on gene expression data, most of these are based on single pathway analyses, and thus do not consider correlations between pathways. In this paper, we propose a hierarchical structural component model for pathway analysis of gene expression data (HisCoM-PAGE), which accounts for the hierarchical structure of genes and pathways, as well as the correlations among pathways. Specifically, HisCoM-PAGE focuses on the survival phenotype and identifies its associated pathways. Moreover, its application to real biological data analysis of pancreatic cancer data demonstrated that HisCoM-PAGE could successfully identify pathways associated with pancreatic cancer prognosis. Simulation studies comparing the performance of HisCoM-PAGE with other competing methods such as Gene Set Enrichment Analysis (GSEA), Global Test, and Wald-type Test showed HisCoM-PAGE to have the highest power to detect causal pathways in most simulation scenarios.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research

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We present the case of a 65-year-old man who complained of painless swelling of the left scrotum for 9 months. Scrotal ultrasonography revealed a mass in the left testis. Serum CA199 and CA242 were significantly elevated. 18F-FDG PET/CT was recommended for identifying potential malignancy and showed several hypermetabolic masses in the pancreas, left testis, and right lung. Resection of left testicular and pancreatic masses and fine-needle biopsy of right pulmonary mass were performed, and subsequent pathology confirmed pancreatic adenocarcinoma metastasizing to the testis and lung.
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Publication date: 15 February 2020Source: Journal of Molecular Structure, Volume 1202Author(s): Intissar Moghdad, Aicha Mbarek, Ferdinando Costantino, Sabrina Nazzareni, Houcine NaïliAbstractThree inorganic-organic hybrid diphosphates, templated by transition metal (2,6-(CH3)2C6H3NH3)2[MII(H2P2O7)2(H2O)2] (MII = Mn, Ni, Zn), were successfully synthesized by low speed of evaporation conditions after using the ion exchange chemical procedure. Their crystal structures were solved from single-crystal X-ray diffraction data. All compounds are isotypic and crystallize in the triclinic system with space group Pī. The cr...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
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Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
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Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
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Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
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Volume 47, Issue 1, December 2019, Page 3920-3928 .
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