The rs10455872-G allele of the LPA gene is associated with high lipoprotein(a) levels and increased aortic valve calcium in a Mexican adult population

Abstract Polymorphisms in the LPA gene have been associated with aortic valve calcification (AVC). There are wide differences in the allelic frequencies, Lp(a) levels, and the association with AVC among ethnic groups. The aim of this study was to determine the association of the LPA gene polymorphisms with Lp(a) levels and risk of developing AVC, in Mexican-Mestizos population. Six LPA polymorphisms (rs10455872, rs7765803, rs6907156, rs1321195, rs12212807 and rs6919346) were genotyped by TaqMan assays in 1,265 individuals without premature coronary artery disease. The presence of AVC was determined by computed tomography. The association of the LPA polymorphisms with AVC, Lp(a), and other cardiovascular risk factors (CVRF) was evaluated using logistic regression analysis. Compared to AA genotype, subjects with AG+GG genotypes had high prevalence of Lp(a) ≥ 30 mg/dL (7.1% vs. 23.7%, p
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research

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ConclusionCommon Iliac Artery Aneurysms should be considered a differential diagnosis of lower abdominal mass. If presenting in this manner the aneurysm can be of significant size and at high risk of rupture, requiring urgent surgical intervention.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionOur results indicated that VISICOIL 0.5 × 5.0 mm and the GAs can be used nearly always for CyberKnife treatment in spite of their much thinner needles than those of cylinder types.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Primary leiomyosarcoma of the bronchus is an extremely rare malignant neoplasm. A 29-year-old man presented with persisting cough and sputum over 1 month. Unenhanced and contrast-enhanced chest CT showed a nodular lesion in the main bronchus of the left lower lobe and multiple enlarged lymph nodes in the mediastinum. Preoperative staging 18F-FDG PET/CT scan displayed a hypermetabolic lesion of the known nodule and mild FDG uptake of mediastinal lymph nodes. The histological examination confirmed bronchial leiomyosarcoma and reactive hyperplasia in lymph nodes.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Authors: Brindhaban A Abstract Rationale: Radiation dose to patients from imaging modalities are measured or calculated to assess the risk of the procedure and compared it to the benefits. Periodic review of image acquisition methods and radiation dose used are essential part of procedure optimization in medical imaging. The aim of this study was to estimate patient radiation dose from single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) using computed tomography (CT) images for attenuation correction. Methods: SPECT and CT image acquisition parameters such as, administered activity...
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
ConclusionsTSMA predicts adverse outcome after pneumonectomy for lung cancer. This marker, readily derived from standard chest CT, identifies patients at increased risk for postoperative complications and may help select patients appropriate for focused rehabilitation prior to pneumonectomy.Graphical abstract
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionsThe construction of digitally reduced 3D models and custom adapted plates enables the surgeon to achieve accurate fixation of complex fracture patterns in theatre which is clearly of benefit to patients. The potential for reduced theatre time also renders this approach more desirable, making this a worthwhile investment despite the additional non-clinical time associated with training and initial expenditure.
Source: Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
ConclusionHistological and microCT analyses yielded different outcomes when a xenograft with higher density and higher mineral content compared with the natural bone was used.
Source: Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
ConclusionsThe L6db–L7mb region should be the first choice for miniscrew implantation in the MBS for the distalization of mandibular dentition.
Source: Progress in Orthodontics - Category: Dentistry Source Type: research
AbstractPurpose of reviewCardiac thrombus formation is a frequent complication of a variety of prevalent diseases. Embolism of cardiac thrombus has the potential to result in significant morbidity and mortality from cerebrovascular and peripheral vascular events.Recent findingsEchocardiography is the most commonly used imaging modality for diagnosing intracardiac thrombus. However, technological advances in computed tomography and magnetic resonance imaging have allowed newer noninvasive modalities to evolve into robust tools for the clinical evaluation of patients suspected of disease.SummaryComplimentary use of these ima...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
ConclusionsOur results suggest that hyperostosis of the posterior longitudinal ligament in OPLL may not be associated with bone strength and bone mineral status at the extremities.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
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