Difficulty of predicting early-onset super-imposed preeclampsia in pregnant women with hemodialysis due to diabetic nephropathy by serum levels of sFlt-1, PlGF, and sEng

AbstractThere are few case reports in which circulating levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and soluble endoglin (sEng) were measured before the onset of super-imposed preeclampsia in women with hemodialysis. A 40-year-old Japanese nulliparous women with hemodialysis due to diabetic nephropathy became pregnant by frozen embryo transfer. Intensive hemodialysis was started at 5  weeks of gestation. Her blood pressure (BP) in the first trimester was around 130/80 mmHg. At 20+3 weeks, she was admitted for close monitoring; her BP was 137/75  mmHg. Her BP increased to 157/88 mmHg at 31+2 weeks, and nifedipine at 20  mg/day was started at 31+6 weeks. However, the serial longitudinal measurements of sFlt-1, PlGF, and sEng did not predict the onset of super-imposed preeclampsia. Cesarean section was performed at 33+6 weeks due to uncontrollable hypertension. A healthy female infant weighing 2138  g was delivered. As for the changes of biomarkers between just before and just after hemodialysis, sFlt-1 was significantly higher just after compared with just before hemodialysis (5774 ± 1875 pg/mL vs. 2960 ± 905 pg/mL, respectively,p 
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research

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AbstractAimsFew studies have assessed the prevalence of diabetes and hypertension among pregnant women in China after the implementation of universal two-child policy. Therefore, the aim of the study was to determine the prevalence of diabetes and hypertension from 2016 to 2018 among pregnant women in Jiangsu, China, after the policy implementation.MethodsWe analysed data from pregnant women who delivered their neonates between 2016 and 2018 in the Northern Jiangsu People ’s Hospital. All pregnant women irrespective of their gestation weeks underwent oral glucose intolerance tests in a fasting state.ResultsA total of...
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
Positive pregnancy and birthing experiences go beyond merely having a healthy mother and baby — so, too, does maternal justice, a term that encompasses broad goals. Affordable, timely, high-quality, equitable, and dignified care during and after pregnancy is essential for all birthing people. Maternal justice is a model of culturally sensitive care that aims to dismantle inequities in maternity care and maximize maternal health and well-being. It rests on human rights and requires us to chip away at racism entrenched in health systems. How do race and ethnicity affect pregnancy and birth? Globally, Black, indigenous,...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Adolescent health Health care disparities Parenting Pregnancy Women's Health Source Type: blogs
Background: Coronavirus disease (COVID-19) is a current global public health emergency. However, current research on the blood test results of pregnant women with COVID-19 is insufficient.Methods: A case-control study was carried out based on clinical blood test results. Pregnant COVID-19 patients, pregnant COVID-19 patients with diabetes, and pregnant COVID-19 patients with hypertension, were assessed in this study. Also, 120 controls were matched by age, parity, fetus number, and presence of chronic disease. T-tests, Chi-square tests, Wilcoxon signed-rank tests, and Kruskal-Wallis tests were used to compare data from the...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
The impact of female abnormalities of body mass index (BMI) and its association with subfertility and increased time to pregnancy (TTP) have been well-characterized (1). This may be due to the impact of BMI on ovulatory status in women, though TTP is increased even among women with a high BMI and reportedly regular cycles (2). Patients with higher BMIs, those in the overweight and obese categories, are at increased risk for gestational issues including gestational diabetes, hypertension, and difficulty with fetal monitoring.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Abstract Stillbirth is among the most devastating pregnancy complications and is also one of the hardest complications to predict. Traditionally, stillbirth risk stratification has incorporated maternal demographic characteristics such as age and ethnicity as well as medical and pregnancy conditions including multiple gestation, chronic hypertension and pregestational diabetes. While these are clear risk factors for stillbirth, they are nonspecific and are often present in live births. PMID: 33006825 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
HORSHAM, PA, September 30, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved SIMPONI ARIA® (golimumab) for patients 2 years of age and older for the treatment of active pJIA and has extended the PsA indication for this same patient population. “This latest FDA approval of SIMPONI ARIA for pediatric use in active pJIA and active PsA not only brings a new option to young patients living with these diseases but also adds to the growing body of evidence for this treatment,” said Mathai Mammen, M.D., Ph.D., Glob...
Source: Johnson and Johnson - Category: Pharmaceuticals Source Type: news
Authors: Qiu J, Liu Y, Zhu W, Zhang C Abstract BACKGROUND Women with normal fasting glucose (FPG) range (5.1 ≤FPG
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
AbstractPurposeTo compare the obstetrical and detailed neonatal outcomes of primipara of advanced maternal age conceiving two sequential singleton pregnancies by IVF with those of primipara conceiving twins by IVF.MethodsA retrospective study of all primiparous women aged  ≤ 38 years and conceived by IVF who delivered sequential singletons or delivered twins at a single tertiary university affiliated medical center between 2011 and 2019. We performed two main comparisons: 1. First vs. second singleton pregnancies. 2. Two singleton pregnancies vs. twin pregnanc ies.ResultsOverall, there were 63 women w...
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
People whose mothers had diabetes were at higher risk of heart attacks, stroke, high blood pressure and diabetes before age 35.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Diabetes Heart Pregnancy and Childbirth Source Type: news
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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