Pregnancy in Women With Systemic Lupus and Lupus Nephritis

Publication date: September 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 5Author(s): Sharon Maynard, Grace Guerrier, Margaret DuffyPregnancy is an altered immunologic state in which hormonal changes impact the immune system to enable maternal tolerance of the fetus. These hormonal and immunologic changes may affect disease activity in systemic lupus erythematosus. Conversely, lupus nephritis and its complications may adversely impact pregnancy. Systemic lupus erythematosus increases the risk of pre-eclampsia and its complications, including preterm birth and intrauterine growth restriction. Comorbidities such as impaired kidney function and hypertension confer additional risk and complexity. Medications used to treat lupus nephritis may impact the fetus, so therapy needs to be tailored to balance maternal benefit and fetal risk. The diagnosis of lupus nephritis during pregnancy can be difficult, as it shares overlapping features with pre-eclampsia. Kidney biopsy is generally safe in pregnancy, and should be considered if the result will affect management. Here we review the clinical aspects of counseling, diagnosis, and management of lupus nephritis in pregnancy.
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research

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AbstractCardiovascular disease (CVD) is a life-limiting comorbidity in patients with chronic kidney disease (CKD). In childhood, imaging studies have demonstrated early phenotypic characteristics including increases in left ventricular mass, carotid artery intima-media thickness, and pulse wave velocity, which occur even in young children with early stages of CKD. Vascular calcifications are the signature of an advanced phenotype and are mainly found in adolescents and young adults treated with dialysis. Association studies have provided valuable information regarding the significance of a multitude of risk factors in prom...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
AbstractBackgroundEnteral feeding by tube in chronic kidney disease (CKD) before 2 years of age improves growth. Whether it is effective after this age is unknown. We assessed whether height and weight SDS changed after tube feeding was started in children with CKD above 2 years of age.MethodsRetrospective study of pre-transplant, pre-pubertal children (
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Resumo O aneurisma de art éria poplítea (AAP) é o mais frequente dos aneurismas periféricos, correspondendo a 85% do total de aneurismas. Normalmente, são assintomáticos, e o diagnóstico, em geral, é feito por meio do exame físico, tendo uma maior incidência no sexo masculino e em idosos. São bilaterais em 50% dos casos e, em 60% das vezes, estão associados a aneurisma de aorta abdominal. Apresentamos um paciente do sexo masculino com 72 anos de idade, com duas massas pulsáteis em ambas as regiões poplíteas, assintom&aac...
Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
Publication date: Available online 9 December 2019Source: Canadian Journal of DiabetesAuthor(s): Lingning Huang, Yongze Zhang, Yunmin Wang, Ximei Shen, Sunjie YanAbstractAimsInvestigate association between diabetic peripheral neuropathy (DPN)and above normal blood pressure in non-hypertensive patients with type 2 diabetes mellitus(T2DM). Compare the achievement of clinical target for DPN and non-DPN withT2DM .MethodsA retrospective survey was administered to 3810 patients with type 2 diabetes. Cases were grouped according to the Toronto Clinical Scoring System (TCSS): Non-DPN, Mild DPN, Moderate DPN and Severe DPN. 1835 pa...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
In conclusion, the aqueous extract A. africanus has anti-implantation effect in female rats and is safe up to 2000 mg/kg bw. In addition, it contains some potential steroidal saponins, which could be used to explain its an ti-implantation activity, however this finding needs further pharmacological studies to confirm the antifertility activities.
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
Abstract Anoectochilus roxburghii (Wall.) Lindl., Orchidaceae, is a Chinese medicinal plant which can be effective for some diseases such as hepatitis, nephritis, pneumonia. Its active ingredient is kinsenoside. The mechanisms of kinsenoside on the liver-protective effect have not been fully explored until today. The present study was aimed to investigate the protective effect and mechanism of kinsenoside on acute alcoholic liver injury. The protected activity of kinsenoside (10, 20 and 40 mg/kg) were investigated on acute alcoholic liver injury in mice. Male C57BL/6 J mice were fed with non-fat feed for 30 days and oral a...
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
Conditions:   Liver Cirrhoses;   Portal Hypertension Interventions:   Diagnostic Test: Esophagogastroduodenoscopy;   Diagnostic Test: Endoscopic ultrasound Sponsor:   Instituto Ecuatoriano de Enfermedades Digestivas Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Fatty Liver Disease Intervention:   Other: A complete cardiovascular and liver characterization will be carried out Sponsors:   Instituto de Investigación Marqués de Valdecilla;   Hospital Universitario Puerta del Hierro Majadahonda.;   Hospital Universitario Ramón y Cajal;   Hospital General Universitario Gregorio Marañón Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Gestational Diabetes Mellitus;   Medical Nutrition Therapy;   Overweight/Obese;   Gut Microbiota;   Adverse Pregnancy Outcomes Interventions:   Dietary Supplement: Prebiotic-containing dairy;   Dietary Supplement: Dietary intervention Sponsor:   Capital Medical University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Hypertension;   Heart Failure;   Hypertensive Heart Disease;   Diastolic Dysfunction Intervention:   Sponsor:   Karolinska Institutet Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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