Alzheimer's Association funds expansion of aging study in longest running birth cohort

(Alzheimer's Association) The Alzheimer's Association and University College London (UCL) are partnering to study brain aging and dementia in 500 individuals whose health and health-related behaviors have been documented since birth. A $7 million grant from the Alzheimer's Association will allow researchers to more accurately detect the influence of both genetics and behaviors on dementia risk across the life course in this unique population.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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CONCLUSION: The low agreement between amyloid PET/CT and previous clinical and instrumental assessments that we found in our study suggests that the amyloid PET/CT provides additional and early information. To perform an early and differential diagnosis of AD could have a great impact on the patient's management and cost of care in order to perform the correct therapeutic interventions and to allow family members to manage adequately the patient's demanding care. PMID: 31802055 [PubMed - in process]
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Hannah Phillips, a PhD candidate in the departments of neuroscience and psychiatry at Upstate, will use the NIH grant to study frontotemporal dementia (FTD), which is the second most common form of dementia after Alzheimer ’s disease.
Source: SUNY Upstate Medical - Category: Universities & Medical Training Tags: News Research Source Type: news
Authors: Kim B, Choi Y, Kim HS, Im HI Abstract Despite decades of research on Alzheimer disease, understanding the complexity of the genetic and molecular interactions involved in its pathogenesis remains far from our grasp. Methyl-CpG Binding Protein 2 (MeCP2) is an important epigenetic regulator enriched in the brain, and recent findings have implicated MeCP2 as a crucial player in Alzheimer disease. Here, we provide comprehensive insights into the pathophysiological roles of MeCP2 in Alzheimer disease. In particular, we focus on how the alteration of MeCP2 expression can impact Alzheimer disease through risk gen...
Source: International Neurourology Journal - Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research
New research in mice suggests that exposure to cadmium can lead to cognitive decline in those with the Alzheimer's risk gene APOE4.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
ABSTRACT The association between Alzheimer's disease (AD) and sleep disturbances has received increasing scientific attention in the last decades. However, little is known about the impact of sleep and its disturbances on the development of preclinical AD stages, such as mild cognitive impairment. This review describes the evolution of knowledge about the potential bidirectional relationships between AD and sleep disturbances exploring recent large prospective studies and meta-analyses and studies of the possible mechanisms through which sleep and the neurodegenerative process could be associated. The review also makes a c...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
A drug that curbs delusions in Parkinson's patients did the same for people with Alzheimer's disease and other forms of dementia. The benefit was clear.
Source: Los Angeles Times - Science - Category: Science Authors: Source Type: news
SAN DIEGO (AP) — A company that claims to have the first drug to slow mental decline from Alzheimer’s disease made its case to scientists Thursday, disclosing more results that may help explain why one study of the experimental medicine succeeded and another failed. Excitement and skepticism have surrounded aducanumab since its developers stopped studies earlier this year because it didn’t seem to be working, then did a stunning about-face in October and said new results suggest it was effective, at a high dose. Thursday’s presentation at an Alzheimer’s conference in San Diego convinced some e...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated CBSN Boston Aducanumab Alzheimer's Disease Source Type: news
A study found that the drug that curbs delusions in Parkinson's patients did the same for people with Alzheimer's and other forms of dementia
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
In this study, we aimed to complement previous phenotypic studies by doing an international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72.MethodsIn this international, retrospective cohort study, we collected data on age at symptom onset, age at death, and disease duration for patients with pathogenic mutations in the GRN and MAPT genes and pathological expansions in the C9orf72 gene through the Frontotemporal Dementia Prevention Initiative and from published papers. We used mixed effects models to explore differences in age at onset, age at death,...
Source: The Lancet Neurology - Category: Neurology Source Type: research
This study compared different methods for collecting data on falls among people with dementia to identify which is most feasible and accurate. Eighty-three dyads, comprised of a community-dwelling person with dementia and their informal carer, participated in the TAi ChI for people with demenTia (TACIT) trial. Falls were collected prospectively over 6 months using monthly calendars, weekly and monthly telephone interviews, and 3-monthly telephone interviews with the carer. Unique falls identified across the reporting methods were combined, and this total was compared against each reporting method in isolation and combinati...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
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