Is there concordance between bone and tendon cultures in patients with foot tissue loss?

Resumo Contexto As infec ções profundas de extremidades representam um desafio para o salvamento de membro dos pacientes. Objetivos Investigar se existe concordância entre as culturas de osso e tecido profundo em pacientes com lesões tróficas de extremidades. Métodos Foi realizado um estudo retrospectivo incluindo 5 4 pacientes com lesões tróficas profundas de extremidades internados, no Complexo Hospitalar Universitário Professor Edgard Santos, Salvador (BA), Brasil. Foram incluídos todos os pacientes que realizaram culturas de lesões tróficas profundas, com duas modalidades de coleta de exame: osso e fr agmentos de tendão profundo. Analisaram-se a concordância, o número total de microrganismos e o número de microrganismos de acordo com a coloração de Gram em ambas as amostras. Resultados Entre os 54 doentes incluídos na amostra, a média de idade foi de 63,6 anos, 80% apresentavam DAOP, 70% eram diabéticos, e 72% hipertensos. Estudando as culturas dos 54 pacientes, 28 amostras (52%) foram completamente concordantes, sendo cultivados os mesmos microrganismos nos fragmentos de tendão profundo e de osso. Houve discordância parcial em 13 amostras (24%), e discordância total em 13 (24% ). Observou-se que cresceu em média 1,62 microrganismo nos fragmentos de tendão profundo, e 1,72 nas amostras de osso. An...
Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research

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Conditions:   Diabetic Foot;   Neuropathic Foot Ulcer;   Chronic Diabetic Ulcer of Left Foot (Diagnosis);   Chronic Diabetic Foot Ulcer of Right Foot Interventions:   Other: Standard-of-care for neuropathic/neuroischemic diabetic foot ulcers;   Drug: S26E Sponsor:   National and Kapodistrian University of Athens Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions/interpretationFour interventions were identified as being effective in preventing foot ulcers in people with diabetes, but uncertainty remains about what works and who is most likely to benefit.
Source: Diabetologia - Category: Endocrinology Source Type: research
Introduction - The diabetic foot ulceration (DFU) has the potential to deteriorate rapidly without a prompt assessment and treatment. Despite there being different healthcare structures across Europe, the General Practitioner (GP), usually plays a key role in coordinating patients care.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
ra Propolis is a natural product resulting from the mixing of bee secretions with botanical exudates. Since propolis is rich in flavonoids and cinnamic acid derivatives, the application of propolis extracts has been tried in therapies against cancer, inflammation, and metabolic diseases. As metabolic diseases develop relatively slowly in patients, the therapeutic effects of propolis in humans should be evaluated over long periods of time. Moreover, several factors such as medical history, genetic inheritance, and living environment should be taken into consideration in human studies. Animal models, especially mice and ...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Introduction - Conflicting evidence exists on the effects of hyperbaric oxygen therapy (HBOT) in the treatment of chronic ischaemic leg ulcers. The aim of this multicentre trial was to investigate whether HBOT, as an adjunct to revascularisation and standard wound care, can improve wound healing and reduce major amputation rates in patients with diabetes and ischaemic lower extremity ulcers.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Abstract Healing in wounds like pressure ulcers, diabetic ulcers, venous ulcers, and arterial insufficiency ulcers is immensely hampered and causes both economic burden and morbidity to patients. These wounds face plethora of hostile conditions like elevated reactive oxygen species (ROS), impaired angiogenesis, senescent fibroblast and deficient stem cells that significantly diminish the probability of self-healing in these wounds. Adipose-derived stem cell therapy (ADSC) presents a promising approach to achieve efficient healing in such cases. To address the complex scenario of chronic wounds, we propose a combin...
Source: Biomacromolecules - Category: Biochemistry Authors: Tags: Biomacromolecules Source Type: research
In conclusion, miRNA-497, with its down-regulation activity for pro-inflammatory cytokines, is proposed as a potential therapeutic agent for diabetic wound healing.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Conditions:   Diabetic Foot Infection;   Non-healing Wound;   Non-healing Diabetic Foot Ulcer Interventions:   Biological: TTAX01;   Other: Standard Care Sponsor:   Tissue Tech Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionThe combination use could enhance the recovery of DFUs, shorten the treatment duration, and reduce the pain during treatment.
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
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