Nutrition, Cancer and Personalized Medicine.

Nutrition, Cancer and Personalized Medicine. Adv Exp Med Biol. 2019;1168:157-168 Authors: Flores-Pérez JA, de la Rosa Oliva F, Argenes Y, Meneses-Garcia A Abstract Cancer is a complex group of diseases where different signaling pathways have been found to be deregulated, mainly related to cell proliferation, angiogenesis, metastasis, evasion of apoptosis and insensitivity to anti-growth sings among others. Diet plays a fundamental role in the treatment of the oncological patients, we must be aware that food can interact with certain types of cancer therapy. On the other hand, cancer therapies sometimes affect the patient's sense of smell, taste, appetite, gastric capacity or nutrient absorption, which often results in malnutrition due to the lack of essential nutriments. In this chapter we will review the effect of different metabolic disorders in cancer and mechanisms of action of some phytochemicals found in different foods like resveratrol, EGCG, curcumin and lycopene. PMID: 31713171 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

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Publication date: 1 April 2020Source: Journal of Molecular Liquids, Volume 303Author(s): Archu Singh, Yub Raj Neupane, Sadat Shafi, Bharti Mangla, Kanchan KohliAbstractIn the rapidly expanding field of nanomedicine, liposomes have been considered as the most successful drug carrier having various clinically approved products. However, their delivery via oral route has been a persistent challenge due to harsh environment of the gastrointestinal tract. Herein, we explored the potential of PEGylation onto liposomes as an effective strategy to protect them from harsh gastric environment and as a successful drug delivery carrie...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
CONCLUSION: Our data show that fluorouracil-based adjuvant chemotherapy does not work for dMMR cases, if not worse. Autophagy inhibition and/or immune checkpoint inhibition might be promising alternative strategies for gastric cancer treatment. IMPLICATIONS FOR PRACTICE: The use of microsatellite instability (MSI) and mismatch repair (MMR) as predictive biomarkers for adjuvant chemotherapy in colorectal cancer has caused a paradigm shift in cancer therapy, although its implications in gastric cancer are still questionable. The data obtained in the current study indicate that MSI-MMR is an independent prognostic factor...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Li D, Cui R, Xu S, Liu Y Abstract Combined administration of different drugs is a widely acknowledged approach for effective cancer therapy. However, the limited targeting, as well as inferior drug loading capacities of current drug delivery systems (DDS), are still the bottleneck for better performance in cancer treatment. Herein, we successfully developed a cancer cell membrane (CM) decorated calcium carbonate (CC) hybrid nanoparticles (HN) for the co-delivery of cisplatin (CDDP) and oleanolic acid (OA). The physicochemical property of HN/CDDP/OA was evaluated, which revealed that the as-prepared DDS was...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Conclusions/implicationsPPI use may impair breast cancer survivors ’ memory, concentration, and quality of life.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
The U.S. Food and Drug Administration approved Blueprint Medicines Corp's oral therapy to treat a rare form of cancer that affects the stomach and small intestine, the agency said on Thursday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
In this study, systematic inhibitor response to ErbB missense mutations in gastric cancer (GC) is investigated by combining computational analysis and experimental assay. The response profile is created for 6 ATP-competitive, reversible inhibitors against 9, 17, 5 and 17 GC-associated missense mutations of ErbB1, ErbB2, ErbB3 and ErbB4 kinase domains, respectively. From the profile a number of potential resistant and sensitive responses are identified theoretically. It is suggested that most ErbB mutations have only a modest effect on inhibitor binding, but few that are located around the kinase active site can influence...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Publication date: Available online 16 December 2019Source: Acta Pharmaceutica Sinica BAuthor(s): Zhenzhen Liu, Taoqian Zhao, Zhonghua Li, Kai Sun, Yundong Fu, Ting Cheng, Jimin Guo, Bin Yu, Xiaojing Shi, Hongmin LiuAbstractUbiquitin specific peptidase 28 (USP28) is closely associated to the occurrence and development of various malignancies, and thus has been validated as a promising therapeutic target for cancer therapy. To date, only few USP28 inhibitors with moderate inhibitory activity have been reported, highly potent and selective USP28 inhibitors with new chemotypes remain to be discovered for pathologically investi...
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research
We reported a case of advanced gastroesophageal junction cancer with distal lymph node metastasis that was successfully treated with chemotherapy, surgical resection, and nivolumab therapy. An aggressive search for biomarkers implying benefit effects of nivolumab should be performed.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Liu H, Mei D, Xu P, Wang H, Wang Y Abstract Yes-associated protein (YAP) has been reported to serve an important role in gastric cancer cell survival and migration. However, the underlying mechanism remains unclear. The aim of present study was to identify the underlying mechanism through which Yap sustains gastric cancer viability and migration. The results of the present study demonstrated that YAP expression was upregulated in gastric cancer MKN-28/74 cells compared with normal gastric GES-1 cells. Functional studies revealed that silencing of YAP inhibited gastric cancer MKN-28/74 cell viability and in...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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