Allergic diseases and long-term risk of autoimmune disorders: longitudinal cohort study and cluster analysis

Conclusions The long-term risks of autoimmune disorders are significantly higher in patients with allergic diseases. Allergic diseases and autoimmune disorders show age- and sex-related clustering patterns.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Original Articles: Asthma and allergy Source Type: research

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This study aims to investigate the efficacy and mechanism of action of TG-C in a rat model of OA. Using the monosodium-iodoacetate (MIA) model of OA, we examined whether TG-C could improve OA symptoms and cartilage structure in rats. Our results showed that TG-C provided pain relief a nd cartilage structural improvement in the MIA OA model over 56 days. In parallel with these long-term effects, cytokine profiles obtained on day 4 revealed increased expression of interleukin-10 (IL-10), an anti-inflammatory cytokine, in the synovial lavage fluid. Moreover, the increased levels of TGF-β1 and IL-10 caused by TG-C in...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: Based on aggregated data, we found that living in close proximity to areas with high grass cover (grasslands, but also residential gardens) may negatively impact child respiratory health. Potential allergic and non-allergic mechanisms that underlie this association include elevated exposure to grass pollen and fungi and reduced exposure to environmental biodiversity. Reducing the dominance of grass in public and private green space might be beneficial to reduce the childhood asthma burden and may simultaneously improve the ecological value of urban green space. PMID: 32980008 [PubMed - in process]
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research
Infectious mononucleosis is a largely benign disease process that occurs secondary to infection with the Epstein-Barr virus. However, it can also present with more serious complications, including auto-immune hemolytic anemia and acute liver failure. Hereditary hemochromatosis is a genetic disorder that leads to organ damage via increased iron uptake and deposition. This case report describes a 25-year-old man who presented with acute liver failure and severe hemolytic anemia. Workup revealed that not only did he have a rare presentation of Epstein-Barr virus-induced acute liver failure and C3-positive IgG-negative hemolyt...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: None of the currently employed therapies for AA are reliably effective nor are they approved for the disease. In this setting, Janus kinase inhibitors emerge as a promising novel treatment, as increasing evidence supports their effectiveness in AA.Skin Appendage Disord
Source: Skin Appendage Disorders - Category: Dermatology Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: Available online 28 September 2020Source: Chemico-Biological InteractionsAuthor(s): Omaima A. Ahmedy, Sherehan M. Ibrahim, Heba H. Salem, Esraa A. Kandil
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Adalimumab could counter hyper-inflammation seen in severe coronavirus casesCoronavirus – latest updatesSee all our coronavirus coverageA commonly used arthritis drug is to be trialled with care home residents who have Covid, after it was observed that those taking it for their joint pains were less likely to end up in hospital with the virus.Older people in care homes, who often have some degree of dementia, tend not to do well in hospital, where they become more confused and may pick up infections. The trial will break new ground by giving the drug to people at care homes, where they can be supervised and monitored...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak UK news Medical research Older people Social care Health NHS Drugs Infectious diseases Science Society Source Type: news
Publication date: September 2020Source: Arthroscopy Techniques, Volume 9, Issue 9Author(s): Felipe Bessa, Jonathan Rasio, Alexander Newhouse, Benedict U. Nwachukwu, Shane Nho
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
ConclusionLaparoscopic surgery for colorectal cancer is a safe and feasible option with better short-term outcomes in patients with sarcopenia.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
Tenascin-C (TNC) is a large multimodular glycoprotein of the extracellular matrix that consists of four distinct domains. Emerging evidence suggests that TNC may be involved in the pathogenesis of osteoarthritis (OA) and rheumatoid arthritis (RA). In this review, we summarize the current understanding of the role of TNC in cartilage and in synovial biology, across both OA and RA. TNC is expressed in association with the development of articular cartilage; the expression decreases during maturation of chondrocytes and disappears almost completely in adult articular cartilage. TNC expression is increased in diseased cartilag...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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