Premature birth, homeostatic plasticity and respiratory consequences of inflammation

Publication date: Available online 13 November 2019Source: Respiratory Physiology &NeurobiologyAuthor(s): Estelle B. Gauda, Gabrielle L. McLemoreABSTRACTInfants who are born premature can have persistent apnea beyond term gestation, reemergence of apnea associated with inflammation during infancy, increased risk of sudden unexplained death, and sleep disorder breathing during infancy and childhood. The autonomic nervous system, particularly the central neural networks that control breathing and peripheral and central chemoreceptors and mechanoreceptors that modulate the activity of the central respiratory network, are rapidly developing during the last trimester (22-37 weeks gestation) of fetal life. With advances in neonatology, in well-resourced, developed countries, infants born as young as 23 weeks gestation can survive. Thus, a substantial part of maturation of central and peripheral systems that control breathing occurs ex-utero in infants born at the limit of viability. The balance of excitatory and inhibitory influences dictates the ultimate output from the central respiratory network. We propose in this review that simply being born early in the last trimester can trigger homeostatic plasticity within the respiratory network tipping the balance toward inhibition that persists in infancy. We discuss the intersection of premature birth, homeostatic plasticity and biological mechanisms leading to respiratory depression during inflammation in former premature infants...
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research

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Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
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Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Depression General Research Sunlight Vitamin D Source Type: blogs
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Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: depression featured self improvement anxiety bad habits chronic stress Source Type: blogs
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Source: Maternal and Child Health Journal - Category: Health Management Source Type: research
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Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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Source: Cord Blood News - Category: Perinatology & Neonatology Authors: Tags: Cord Blood pregnancy Source Type: blogs
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Source: Cord Blood News - Category: Perinatology & Neonatology Authors: Tags: Cord Blood pregnancy Source Type: blogs
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