A Study to Assess the Safety and Efficacy of Etrasimod in Subjects With Moderate-to-Severe Atopic Dermatitis
Condition: Atopic Dermatitis Interventions: Drug: Etrasimod; Drug: Etrasimod matching placebo Sponsor: Arena Pharmaceuticals Recruiting
Condition: Atopic Dermatitis Intervention: Drug: Upadacitinib Sponsor: AbbVie Not yet recruiting
Publication date: Available online 10 December 2019Source: Pharmacology &TherapeuticsAuthor(s): Lingling Zhang, Wei WeiAbstractAs a Traditional Chinese Medicine, Paeonia lactiflora Pallas has been used to treat pain, inflammation and immune disorders for more than 1000 years in China. Total glycoside of paeony (TGP) is extracted from the dried root of Paeonia lactiflora Pallas. Paeoniflorin (Pae) is the major active component of TGP. Our research group has done a lot of work in the pharmacological mechanisms of Pae and found that Pae possessed extensive anti-inflammatory and immune regulatory effects. Pae could inhib...
One of the genetic predisposing factors for atopic dermatitis (AD) is abnormal barrier function in the stratum corneum. Mutations in the filaggrin gene (FLG) have become apparent as a cause of this abnormal barrier function . In addition, functional lipids in the epidermis, especially ω-O-esterified ultra-long-chain acylceramide (EOS), are important for skin barrier function . The corneocyte lipid envelope (CLE) is also an essential structure for proper stratum corneum barrier function .
Conclusion: Increased IFN-κ in psoriasis may be caused by injured cells-released nucleic acids, increased IFN-γ and self-activation. Its enhancement may contribute to the etiology of the disease by enhancing TNFA and IL17A gene expression. PMID: 31819584 [PubMed]
Recent studies have highlighted the multidimensional effect of atopic dermatitis (AD) and urticaria. Patient burden for these conditions is largely driven by the intense itching, sleep disturbance, comorbidities, and mental health illness associated with these diseases.1-3 Immunologic, microbial, and epithelial interactions have been reported to play an important role in AD.4,5 Novel therapies and management approaches are targeting the mechanisms underlying AD and urticaria.6,7 The current issue of the Annals contains 3 outstanding reviews that update readers on the pathophysiology and evolving treatments for AD and chronic urticaria.
We describe the gross and histological lesions found in 78 post-hatchling loggerhead sea turtles (Caretta caretta) that died during captive rearing in the conservation programme of the Cape Verde-Canary Islands, initiated with 113 hatchlings. The main organ systems affected were respiratory (57.69%), integumentary (41.02%) and digestive (41.02%), affecting 94.87% of the animals. Other less frequently affected organ systems were cardiovascular (3.85%), excretory (3.85%), muscular (2.56%) and reproductive (1.28%). The most common lesions were different types of dermatitis (41.02%), mainly ulcerative and/or heterophilic ulcer...
This systematic review and meta-analysis investigates the risk of noncutaneous and cutaneous cancers in patients with atopic dermatitis compared with the general population without atopic dermatitis.
Human skin harbors a diverse group of microorganism that form complex communities and involve in a variety of complex molecular and cellular processes inside and outside the skin , and even influence gene expression in skin . These microbiota interact directly with skin cells and play a central role in skin physiology and disease . Many of evidence suggest a role for microorganisms in noninfectious skin diseases, such as atopic dermatitis (AD), rosacea, psoriasis, and acne . However, the origin of many skin diseases is multifactorial and in some cases, such as the sensitive skin syndrome (SS), the role of micro...
ConclusionOur aggregate findings suggest that most APTs, but not dust mite, behave like conventional patch tests to low ‐potency allergens. They are more likely to be positive in patients with chronically inflamed skin and to identify allergens that cause SCD. The higher prevalence of APT positivity to foods in young children is consistent with food allergy as a trigger of AD (also known as SCD) being more common i n children than adults. Positive APTs define patients who may have SCD; negative APTs may guide elimination diets.