Celecoxib Through Surgery and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer

Conditions:   Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Nasal Cavity and Paranasal Sinus Carcinoma;   Oral Cavity Carcinoma;   Pathologic Stage III HPV-Mediated (p16-Positive) Or opharyngeal Carcinoma AJCC v8;   Pathologic Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Recurrent Hypopharyngeal Carcinoma;   Recurrent Laryngeal Carcinoma;   Recurrent Nasal Cavity and Paranasal Sinus Carcinoma;   Recurrent Oral Cavity Carcinoma;   Recurrent  Oropharyngeal Carcinoma;   Stage III Hypopharyngeal Carcinoma AJCC v8;   Stage III Laryngeal Cancer AJCC v8;   Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8;   Stage IV Hypopharyngeal Carcinoma AJCC v8;   Stage IV Laryngeal Cancer AJCC v8;   Stage IV Oropharyn geal (p16-Negative) Carcinoma AJCC v8;   Stage IVA Hypopharyngeal Carcinoma AJCC v8;   Stage IVA Laryngeal Cancer AJCC v8;   Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8;   Stage IVB Hypopharyngeal Carcinoma AJCC v8;   Stage IVB Laryngeal Cancer&n...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Opinion statementStandard-of-care treatment for the majority of patients with locoregionally advanced squamous cell carcinoma of the head and neck (SCCHN) is either upfront surgery followed by adjuvant treatment as indicated by intraoperative or pathologic findings or concurrent chemoradiation reserving surgical salvage for non-responsive disease. An attempt at upfront complete resection should be pursued if feasible in patients with oral cavity or paranasal sinus primary tumors. Given multimodality treatment paradigms, patients with locoregionally advanced SCCHN should be managed in a multidisciplinary setting. Modern rad...
Source: Current Treatment Options in Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Nasal Cavity and Paranasal Sinus Carcinoma;   Oral Cavity Carcinoma;   Pathologic Stage III HPV-Mediated (p16-Positive) Or opharyngeal Carcinoma AJCC v8;   Pathologic Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Recurrent Hypopharyngeal Carcinoma;   Recurrent Laryngeal Carcinoma;   Recurrent Nasal Cavity and Paranasal Sinus ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: The selection of lymph node target volumes for head and neck cancers treated with IMRT/VMAT or other highly conformal techniques (e.g. proton therapy) requires a rigorous approach. This updated proposal of selection should help clinicians for the selection of lymph nodes target volumes and contribute to increase consistency. PMID: 31005201 [PubMed - in process]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
Salivary gland malignancies (SGM) are relatively rare but are rising in incidence [1]. SGM account for 3–5% of all head and neck cancers and can occur in major glands (parotid, submandibular, and sublingual) or minor glands within the mucosal lining of the oral cavity, oropharynx, and nasal cavity. The most common histological subtypes of SGM are adenoid cystic carcinoma, mucoepidermoid carcinoma, and acinic cell carcinoma [2]. Radiation therapy has been shown to be effective at increasing the survival of high-risk patients who have close or positive margins, lymph node metastasis, locally advanced disease, bone or n...
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
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