A Phase II Study in Adult Patients With Moderate to Severe Atopic Dermatitis

Condition:   Atopic Dermatitis Intervention:   Drug: Drug: SHR0302 Sponsor:   Reistone Biopharma Company Limited Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Condition:   Atopic Dermatitis Intervention:   Drug: Upadacitinib Sponsor:   AbbVie Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 10 December 2019Source: Pharmacology &TherapeuticsAuthor(s): Lingling Zhang, Wei WeiAbstractAs a Traditional Chinese Medicine, Paeonia lactiflora Pallas has been used to treat pain, inflammation and immune disorders for more than 1000 years in China. Total glycoside of paeony (TGP) is extracted from the dried root of Paeonia lactiflora Pallas. Paeoniflorin (Pae) is the major active component of TGP. Our research group has done a lot of work in the pharmacological mechanisms of Pae and found that Pae possessed extensive anti-inflammatory and immune regulatory effects. Pae could inhib...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Conclusion: Increased IFN-κ in psoriasis may be caused by injured cells-released nucleic acids, increased IFN-γ and self-activation. Its enhancement may contribute to the etiology of the disease by enhancing TNFA and IL17A gene expression. PMID: 31819584 [PubMed]
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
Recent studies have highlighted the multidimensional effect of atopic dermatitis (AD) and urticaria. Patient burden for these conditions is largely driven by the intense itching, sleep disturbance, comorbidities, and mental health illness associated with these diseases.1-3 Immunologic, microbial, and epithelial interactions have been reported to play an important role in AD.4,5 Novel therapies and management approaches are targeting the mechanisms underlying AD and urticaria.6,7 The current issue of the Annals contains 3 outstanding reviews that update readers on the pathophysiology and evolving treatments for AD and chronic urticaria.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Editorial Source Type: research
We describe the gross and histological lesions found in 78 post-hatchling loggerhead sea turtles (Caretta caretta) that died during captive rearing in the conservation programme of the Cape Verde-Canary Islands, initiated with 113 hatchlings. The main organ systems affected were respiratory (57.69%), integumentary (41.02%) and digestive (41.02%), affecting 94.87% of the animals. Other less frequently affected organ systems were cardiovascular (3.85%), excretory (3.85%), muscular (2.56%) and reproductive (1.28%). The most common lesions were different types of dermatitis (41.02%), mainly ulcerative and/or heterophilic ulcer...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
Human skin harbors a diverse group of microorganism that form complex communities and involve in a variety of complex molecular and cellular processes inside and outside the skin [1], and even influence gene expression in skin [2]. These microbiota interact directly with skin cells and play a central role in skin physiology and disease [3]. Many of evidence suggest a role for microorganisms in noninfectious skin diseases, such as atopic dermatitis (AD), rosacea, psoriasis, and acne [4]. However, the origin of many skin diseases is multifactorial and in some cases, such as the sensitive skin syndrome (SS), the role of micro...
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
ConclusionOur aggregate findings suggest that most APTs, but not dust mite, behave like conventional patch tests to low ‐potency allergens. They are more likely to be positive in patients with chronically inflamed skin and to identify allergens that cause SCD. The higher prevalence of APT positivity to foods in young children is consistent with food allergy as a trigger of AD (also known as SCD) being more common i n children than adults. Positive APTs define patients who may have SCD; negative APTs may guide elimination diets.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Publication date: Available online 10 December 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): A. Badihi, M. Frušić-Zlotkin, Y. Soroka, S. Benhamron, T. Tzur, T. Nassar, S. BenitaAbstractSystemic cyclosporine A (CsA) therapy shows efficacy in the treatment of recalcitrant severe atopic dermatitis (AD) but elicits severe side-effects. Thus, a topical formulation of CsA nanocapsules (NCs), able to potentially bypass these drawbacks, was developed. CsA-NCs were shown to enhance drug penetration into the various layers of porcine ear skin. Furthermore, the encapsulated CsA was biologically acti...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Authors: Sun L, Liu W, Zhang LJ Abstract As the key defense molecules originally identified in Drosophila, Toll-like receptor (TLR) superfamily members play a fundamental role in detecting invading pathogens or damage and initiating the innate immune system of mammalian cells. The skin, the largest organ of the human body, protects the human body by providing a critical physical and immunological active multilayered barrier against invading pathogens and environmental factors. At the first line of defense, the skin is constantly exposed to pathogen-associated molecular patterns (PAMPs) and damage-associated molecul...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Condition:   Atopic Dermatitis Interventions:   Other: Clinical examination;   Procedure: Biopsies;   Other: Blood test Sponsor:   University Hospital, Toulouse Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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