AHA: Vitamin D, Omega-3 Do Not Cut Heart Failure Hospitalization

THURSDAY, Nov. 14, 2019 -- Neither vitamin D nor marine omega-3 (n-3) fatty acid supplementation significantly reduces the rate of first heart failure hospitalization, according to a research letter published online Nov. 11 in Circulation to...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Authors: Yi C, Si L, Xu J, Yang J, Wang Q, Wang X Abstract Myocardial ischemia-reperfusion injury (MIRI) is a major cause of heart failure in patients with coronary heart disease. The excessive accumulation of reactive oxygen species (ROS) during MIRI induces the overactivation of an autophagic response, which aggravates myocardial cell damage. Asiatic acid (AA) is a triterpenoid compound, which is extracted from Centella asiatica and exhibits a variety of pharmacological effects such as hepatoprotective, neuroprotective and antioxidant. However, the association of AA with autophagy in MIRI is not fully understood....
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
A new meta-analysis furthers the evidence for the benefits of catheter ablation in patients with heart failure.European Heart Journal
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news
AbstractDrug therapies for people with heart failure and preserved ejection fraction (HFpEF) are often limited to diuretics to improve symptoms as no therapies demonstrate a mortality benefit in this cohort. People with diabetes have a high risk of developing HFpEF and vice versa, suggesting shared pathophysiological mechanisms exist, which in turn engenders the potential for shared treatments. Dapagliflozin is a sodium –glucose co-transporter 2 (SGLT2) inhibitor which has demonstrated significantly improved cardiovascular and hospitalisation for heart failure (HHF) outcomes in previous cardiovascular outcome tr...
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
ConclusionsGLP-1RAs and SGLT2is lead to similar benefits on MACE, CVD, MI, and ACD in adults with type  2 diabetes. The benefit from SGLT2is on HHF is greater than that from GLP-1RAs, while GLP-1RAs vs. placebo significantly reduce stroke whereas SGLT2is do not. The two drug classes reduce cardiovascular events independent of reductions of systolic blood pressure and body weight.
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
AbstractIn the last decade, cardio-oncology has become a discipline on its own, with tremendous research going on to unravel the mechanisms underpinning different manifestations of cardiotoxicity caused by anticancer drugs. Although this domain is much broader than the effect of chemotherapy alone, a lot of questions about anthracycline-induced cardiotoxicity remain unknown. In this invited review, we provide insights in molecular mechanisms behind anthracycline-induced cardiotoxicity and put it in a clinical framework emphasizing the need for patients to understand, detect, and treat this detrimental condition.
Source: Current Heart Failure Reports - Category: Cardiology Source Type: research
AbstractPurpose of ReviewThe available platforms for temporary circulatory support (TCS) have expanded to include impeller technologies in addition to the traditional approaches with centrifugal pumps and intra-aortic counterpulsation. We review the evidence for competing technologies, relative risk, and benefit of individual TCS platforms and provide a consensus opinion in the context of our institutional experience.Recent FindingsTrans-aortic axial flow devices (Impella) have significantly impacted the support of patients with cardiogenic shock. Despite the absence of prospective randomized data, the use of both percutan...
Source: Current Heart Failure Reports - Category: Cardiology Source Type: research
CONCLUSION: In patients with AHF, serum CA125 levels are associated more significantly than NT-proBNP with a state of congestion. PMID: 32951882 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
TUESDAY, Sept. 22, 2020 -- From 2008 to 2017, there were decreases in the rates of recurrent myocardial infarction (MI), recurrent coronary heart disease (CHD) events, heart failure hospitalization, and all-cause mortality in both men and women,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Brigham and Women ’s Hospital received the American Heart Association’s 2020 Get With The Guidelines-Heart Failure Gold Plus Quality Achievement Award. This achievement recognizes hospitals that demonstrate a commitment to ensuring heart failure patie
Source: BWH News - Category: Hospital Management Source Type: news
End-stage renal disease (ESRD) patients are at high cardiovascular risk, and myocardial fibrosis (MF) accounts for most of their cardiac events. The purpose of this study is to investigate the prognostic value...
Source: BMC Cardiovascular Disorders - Category: Cardiology Authors: Tags: Research article Source Type: research
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