Lower prednisone dosing for steroid-sensitive nephrotic syndrome relapse: a prospective randomized pilot study

Conclusion: In the present study, treatment of childhood steroid sensitive nephrotic syndrome relapse with prednisone 1 –1.5 mg/kg/day led to a significantly lower cumulative dose than the standard dose. Treatment with a lower dose may be equally safe and effective to the standard dose.What is Known:• Relapses of steroid-sensitive nephrotic syndrome are traditionally treated with standard-dose steroids.• Treatment with corticosteroids may have significant adverse effects mainly with long-term use.What is New:• Treatment of steroid sensitive nephrotic syndrome relapse with 1–1.5 mg/kg/day prednisone may lead to a significantly lower cumulative dose.• Treatment with a lower steroid dose may be as effective as the standard dose in achieving remission of steroid sensitive nephrotic syndrome relapse.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research