Pregnancy And Autoimmune Diseases

Publication date: Available online 14 November 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Emily C. SomersAbstractAutoimmune diseases (AID) are more prevalent in women than men, and pregnancy-related factors such as hormonal modulation and fetal microchimerism may influence future risk of maternal AID. For women with AID, optimizing reproductive health requires a continuum of multidisciplinary care that initiates well before the desire for pregnancy is articulated. Family planning is essential so that pregnancy can be timed when disease is stable and to allow for appropriate medication adjustments. When contraception is used, choice of method needs to take into consideration underlying disease and laboratory features. For females undergoing gonadotoxic therapy, options for preserving ovarian health and fertility warrant consideration, even among those who are not contemplating future pregnancy. Both maternal and fetal outcomes are optimized with multispecialty care and close monitoring during pregnancy and the post-partum period, and when treatment regimens compatible with pregnancy are maintained in order to control underlying disease activity.
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research

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Authors: Sibtain S, Sinha P, Manoharan M, Azeez A Abstract Vitamin D deficiency (Vit D deficiency) is a global health concern and a common occurrence especially among pregnant women. It has been suggested that Vit D deficiency has implications on both the mother and the foetus. Vitamin D deficiency is the most under-diagnosed nutritional deficiency in the world, affecting the majority of individuals, irrespective of their geography, gender, age or race. Vitamin D deficiency is also linked with several diseases (autoimmune diseases, cancer, cardiovascular, dementia and musculoskeletal diseases). Therefore, appropria...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
Publication date: Available online 2 December 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Jamilya Khizroeva, Cecilia Nalli, Victoria Bitsadze, Andrea Lojacono, Sonia Zatti, Laura Andreoli, Angela Tincani, Yehuda Shoenfeld, Alexander MakatsariyaAbstractInfertility consists by definition in ” failure to achieve a clinical pregnancy after 12 months or more of regular unprotected intercourse” while the term subfertility means a delay to achieve pregnancy. Several factors can contribute to infertility or subfertility in patients with systemic autoimmune diseases. The asso...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Authors: Konuralp Atakul B, Koc A, Adiyaman D, Kuyucu M, Sahingoz Yildirim AG, Saka Guvenc M, Erdogan KM, Sengul B, Oztekin DC Abstract The aim of this study was to evaluate the maternal and foetal factors affect higher cell-free DNA (cfDNA) levels and to investigate a possible relationship between high cfDNA levels and adverse perinatal outcomes. From a total of 4594 women who underwent non-invasive prenatal testing from January 2016 to March 2018 in our hospital, 112 women had high levels of cfDNA, which was not appropriate for testing. Maternal characteristics and perinatal outcomes were compared between patient...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
Publication date: Available online 13 November 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Cecilia Nalli, Jessica Galli, Maria Grazia Lazzaroni, Laura Andreoli, Elisa Fazzi, Angela TincaniAbstractAutoimmune diseases often affect young women and this may represent a problem in family planning. Pregnancies in these patients may carry several complications but nowadays the continued amelioration in treatment and management has greatly improved the pregnancy outcome. The main concern of these women obviously is the short- and long-term outcome of their children. A child born from a wo...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
This article reviews the immunomodulatory role of vitamin D in autoimmune diseases and pregnancy. In particular, we will describe the role of vitamin D from conception until delivery, including the health of the offspring. This review highlights an observational study where hypovitaminosis D was correlated with decreased fertility, increased disease activity, placental insufficiency, and preeclampsia in women with APS.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Membranous nephropathy and anti –glomerular basement membrane glomerulonephritis are characterized by the deposition of antibodies that recognize specific glomerular epitopes. These antibodies may develop in autoimmune diseases, after exposure to new antigens or after passive maternal transfer, such as in neonatal membranous nep hropathy secondary to in utero transfer of anti–neutral endopeptidase protein Igs. In this issue of Kidney International, Abrahamson et al. reported a murine model of passive anti–glomerular basement membrane disease caused by antibody transfer from pregnant mice to their offspring.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
Many dominant T cell variants decline during pregnancy and reappear afterward, possibly explaining why relapses of the autoimmune disease are less common when women are expecting.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
This article aims to describe the current seek medical status of chronic liver diseases and discuss a stage-based consulting medical model for chronic liver diseases in China mainland, which would contribute to make rational use of limited medical resources and help to address National Health China 2030 strategy initiated by the Chinese government. PMID: 31711913 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Publication date: Available online 13 November 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Cecilia Nalli, Jessica Galli, Maria Grazia Lazzaroni, Laura Andreoli, Elisa Fazzi, Angela TincaniAbstractAutoimmune diseases often affect young women and this may represent a problem in the family planning. Pregnancies in these patients may carry several complications but nowadays the continue amelioration in treatment and management have greatly improved the pregnancy outcome. The main concern of these women obviously are the short- and long-term outcome of their children. A child born from...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
In conclusion, there is an increased prevalence of serum autoimmunity in patients with fertility disorders, possibly with the efficacy of an immunomodulatory treatment to confront prospective therapeutic studies. PMID: 31727487 [PubMed - as supplied by publisher]
Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research
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