Frequency and Dynamics of Non-motor Symptoms Presentation in Hispanic Patients With Parkinson Disease
The clinical phenotype of Parkinson's disease (PD) encompasses a wide range of non-motor symptoms (NMS) compromising the quality of life of affected patients. Currently, information about NMS in PD is scarce among Hispanic populations. Furthermore, few studies have reported the temporal pattern of NMS presentation. We conducted a cross-sectional study aimed to describe the frequency and time of NMS occurrence in Hispanic patients with PD using the self-completed NMS questionnaire (NMSQuest). Participants were interrogated about the time of each NMS presentation respect to the onset of motor symptoms. The frequency of NMS was described according to gender, age at disease onset, disease duration and Hoehn and Yahr (H&Y) stage. We enrolled 120 patients, 73.33% males and 26.66% females, with a mean age of 63.33 ± 8.60 years. All the participants presented at least 1 NMS. The median number of NMS per patient was 12. The most frequent NMS domains were miscellaneous, urinary tract, sleep/fatigue, and gastrointestinal tract symptoms, with no significant gender differences. The most frequent individual NMS were nocturia, urinary urgency, feeling sadness, and constipation. Any patient reported NMS before the onset of motor manifestations. The pattern of occurrence of NMS domains in our population was as follows: attention/memory, cardiovascular, gastrointestinal tract, perceptual problems/hallucinations, mood/cognition, urinary, miscellaneous, sleep/fatigue, and sexual function....
Conditions: Apnea, Obstructive Sleep; Obesity Intervention: Device: Bioelectrical Impedance Analysis (BIA) Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital Recruiting
Condition: Insomnia Intervention: Behavioral: Su-Man formula massage oil Sponsor: China Medical University Hospital Completed
Condition: Parkinson Disease Intervention: Other: Physical therapy Sponsor: Universitatea de Medicina si Farmacie Iuliu Hatieganu Completed
Condition: Adolescent Problem Behavior Intervention: Behavioral: Group/Cohort 2: PAP Sponsors: Association Tunisienne d'Etude&de Recherche sur l'Ath érosclérose; Biochimie Clinique LR99ES11; Department of Biochemistry, La Rabta Hospital, Tunisia.; Université de Toulon Not yet recruiting
Journal of Child and Adolescent Psychopharmacology, Ahead of Print.
Conclusions: Our data are in accordance with previous findings outlining that N + insomniacs have higher PSQI scores than N-. Our results do not confirm the suggested association between napping and depressive or obsessive-compulsive symptoms. Conversely, we found a statistically significant difference (p = 0.0014) in EAT scores in N + and N-. Hyperarousal and REM sleep instability in insomniac patients may create an unbalance of the neuroendocrine hypothalamic regulation leading to an appetite alteration. PMID: 31790624 [PubMed - as supplied by publisher]
CONCLUSIONS In middle-aged and elderly individuals without CKD, arterial stiffness determined by obesity, dyslipidemia and increased pulse pressure, was significantly associated with increased serum levels of cystatin C. PMID: 31793519 [PubMed - in process]
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