Diverse and flexible transmission of fosA3 associated with heterogeneous MDR regions in Salmonella enterica serovars Typhimurium and Indiana isolates.

Diverse and flexible transmission of fosA3 associated with heterogeneous MDR regions in Salmonella enterica serovars Typhimurium and Indiana isolates. Antimicrob Agents Chemother. 2019 Nov 11;: Authors: Fang LX, Jiang Q, Deng GH, He B, Sun RY, Zhang JF, Cen DJ, Miao YY, Wang D, Guo WY, Sun J, Liu YH, Liao XP Abstract We identified fosA3 at a rate of 2.6% in 310 Salmonella isolates from food animals in Guangdong province, China. The fosA3 gene was genetically linked to diverse antibiotic resistance genes (ARGs) including mcr-1, bla CTX-M-14/55, oqxAB and/or rmtB These gene combinations were embedded in heterogeneous fosA3-containing multidrug resistance regions on the transferable ST3-IncHI2 and F33:A-:B- plasmids as well as the chromosome. This indicated a great flexibility of fosA3 co-transmission with multiple important ARGs among Salmonella. PMID: 31712202 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research