Integral Molecular to advance vaccine discovery with NIH contract for $5.5 million

(Integral Molecular) The NIH has awarded Integral Molecular a contract which will provide up to $5.5M over the next five years to define antibody responses to pathogenic viruses including Zika, Marburg and equine encephalitis viruses (EEV), aiding the discovery of vaccines and therapeutics against these currently untreatable and often lethal viruses.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Review recent changes in ACIP's recommendations for pneumococcal conjugate vaccine use in older adults.Morbidity &Mortality Weekly Report
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Publication date: Available online 10 December 2019Source: Fish &Shellfish ImmunologyAuthor(s): Qishuo Wang, Tianzeng Fu, Xincang Li, Qian Luo, Jinjing Huang, Yongcan Sun, Xuepeng WangAbstractStreptococcus agalactiae and Streptococcus iniae are major bacterial pathogens of tilapia that can cause high mortality concomitant with large economic losses to aquaculture. Although development of vaccines using formalin-killed bacteria to control these diseases has been attempted, the mechanism of immunity against streptococcal infections and the cross-protective ability of these two bacteria remains unclear. To explore the imm...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
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Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 9 December 2019Source: Fish &Shellfish ImmunologyAuthor(s): Jianlin Chen, Zhenwei Chen, Wenji Wang, Suying Hou, Jia Cai, Liqun Xia, Yishan LuAbstractNocardia seriolae, a Gram-positive pathogen, has been identified as the causative agent of fish nocardiosis. DNA vaccination has been proven to be effective in conferring protection against bacterial infection in fish. The 30S ribosomal protein S1 (RpsA) and 50S ribosomal protein L7/L12 (RplL) were identified to be the common immunodominant antigens of three fish pathogenic Nocardia (N. seriolae, N. salmonicida and N. asteroids) by immuno...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Studies focused on development of an attenuated vaccine against Mycobacterium avium subsp. paratuberculosis (Map), the causative agent of paratuberculosis (Ptb) in cattle and other species, revealed that deletion of relA, a global gene regulator, abrogates the ability of Map to establish a persistent infection. In the absence of relA, cattle develop CD8 cytotoxic T cells (CTL) with the ability to kill intracellular bacteria. Analysis of the recall response to a relA mutant, Map/ΔrelA, with cells from a vaccinated steer demonstrated that a 35-kDa membrane peptide (MMP) is one of the targets of the response. This obser...
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Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news
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Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
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Source: Antiviral Therapy - Category: Virology Source Type: research
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Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
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