Prediction of Epitope-Based Peptide Vaccine Against the Chikungunya Virus by Immuno-informatics Approach.

Prediction of Epitope-Based Peptide Vaccine Against the Chikungunya Virus by Immuno-informatics Approach. Curr Pharm Biotechnol. 2019 Nov 12;: Authors: Anwar S, Mourosi JT, Khan MF, Hosen MJ Abstract Chikungunya is an arthropod-borne viral disease characterized by abrupt onset of fever frequently accompanied by joint pain, which has been identified in over 60 countries in Africa, Americas, Asia, and Europe. Regardless of the availability of molecular knowledge of this virus, no definite vaccine or other remedial agents have been developed yet. In the present study, a combination of B-cell and T-cell epitope predictions, followed by molecular docking simulation approach has been carried out to design a potential epitope-based peptide vaccine, which can trigger a critical immune response against the viral infections. A total of 52 sequences of E1 glycoprotein from the previously reported isolates of Chikungunya outbreaks were retrieved and examined through in silico methods to identify a potential B-cell and T-cell epitope. From the two separate epitope prediction servers, five potential B-cell epitopes were selected, among them "NTQLSEAHVEKS" was found highly conserved across strains and manifests high antigenicity with surface accessibility, flexibility, and hydrophilicity. Similarly, two highly conserved, non-allergenic, non-cytotoxic putative T-cell epitopes having maximum population coverage were screened to bind with the HLA-C 12*03 molecul...
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research

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Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
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Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
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Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
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Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
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Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
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Source: Journal of Water Sanitation and Hygiene for Development - Category: International Medicine & Public Health Tags: J Water Sanit Hyg Dev Source Type: research
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Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
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Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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