Cardiovascular rEmodelling in living kidNey donorS with reduced glomerular filtration rate: rationale and design of the CENS study.

Conclusions: The present study seeks to provide new insight in the pathophysiological mechanisms linking reduced kidney function to cardiovascular disease. In addition, we aim to enlighten predictors of adverse cardiovascular outcome in living kidney donors. The study is registered at Clinical-Trials.gov (identifier: NCT03729557). PMID: 31718316 [PubMed - as supplied by publisher]
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research

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Purpose of review Despite improvement in short-term renal allograft survival in recent years, renal transplant recipients (RTR) have poorer long-term allograft outcomes. Allograft function slowly declines with periods of stable function similar to natural progression of chronic kidney disease in nontransplant population. Nearly all RTR transitions to failing renal allograft (FRG) period and require transition to dialysis. Conservative chronic kidney disease management before transition to end-stage renal disease is an increasingly important topic; however, there is limited data in RTR regarding how to delay dialysis init...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: NOVEL THERAPEUTIC APPROACHES IN NEPHROLOGY AND HYPERTENSION: Edited by Kamyar Kalantar-Zadeh and Ekamol Tantisattamo Source Type: research
This study was conducted in 60 donors from January 2016 to December 2017. We performed a retrospective review of consecutive patients who underwent transperitoneal right LLDN at our unit.ResultsLLDRN was successfully performed in all subjects by the same surgeons. There were 48 males and 12 females. Among 60 cases, 47 donors had single renal artery and vein, 2 cases had 1 artery and 2 veins, and 5 donors had 2 arteries and 1 vein, and the rest had 2–3 arteries with 1–3 veins. Operative time (OT) was 142.60 ± 33.73 min. Warm ischemic time (WIT) was 2.64 ± 0.76 min. The...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
ConclusionsSeveral programs are still reluctant to allow potential donors with nephrolithiasis to donate. There is an unmet need to develop evidence-based guidelines to optimize outcomes in this population of kidney donors with nephrolithiasis and their recipients.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
Abstract Kidney transplant is a choice option for treatment of chronic kidney failure because it is associated with cost-effective and normal quality of life. To increase the number of living kidney donors, laparoscopic and minimal invasive modalities have been introduced. Here, we present a case of a living donor with an extremely rare complication after laparoscopic donor nephrectomy that presented as massive chylous ascites. Kidney donor operation can be performed with the use of 3 modalities: traditional open, laparoscopic, and open with minimally invasive. All 3 modalities may be associated with some complica...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Tags: Exp Clin Transplant Source Type: research
Conditions:   Opioid Use;   Kidney Diseases;   Pain, Postoperative;   Postoperative Complications;   Postoperative Nausea and Vomiting Interventions:   Procedure: multimodal pain management;   Other: goal directed fluid management;   Other: preoperative carbohydrate loading;   Procedure: Donor nephrectomy;   Procedure: regional anesthesia Sponsor:   Thomas Jefferson University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract BACKGROUND: When the blood supply ceases in a deceased organ donor, ischaemic injury starts. Kidneys are cooled to reduce cellular metabolism and minimize ischaemic injury. This cooling is slow and kidneys are lukewarm during nephrectomy. Smaller single-centre studies have shown that prolonged donor nephrectomy time decreases early kidney transplant function, but the effect on long-term outcome has never been investigated in large multicentre cohort studies. METHODS: The relationship between donor nephrectomy time and death-censored graft survival was evaluated in recipients of single adult-to-adult,...
Source: The British Journal of Surgery - Category: Surgery Authors: Tags: Br J Surg Source Type: research
ConclusionThis case describes our comprehensive approach in this complex surgical scenario to preserve donor safety and provide an optimal kidney graft.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Abstract INTRODUCTION: While medically induced end-stage renal disease (m-ESRD) has been well-studied, outcomes in patients with surgically induced ESRD (s-ESRD) are unknown. We sought to quantitatively compare the non-oncological outcomes for s-ESRD and m-ESRD in a large population-based cohort. METHODS: Medicare patients>65 years old initiating hemodialysis were identified using the U.S. Renal Data System database (2000‒2012). Metastatic cancer, prior transplant history, and nephrectomy for polycystic kidney disease were exclusion criteria. Patients were classified as having s-ESRD or m-ESRD based on h...
Source: Canadian Urological Association Journal - Category: Urology & Nephrology Authors: Tags: Can Urol Assoc J Source Type: research
The objective of this study was to evaluate the technique of embolization of polycystic kidneys to reduce their volume before heterotopic renal transplantation.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Abstracts Presented to the French Society for Vascular and Endovascular Surgery Source Type: research
What do we currently know about the long-term effects of donor nephrectomy on living kidney donors?Nephrology Dialysis Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Transplantation Journal Article Source Type: news
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