Meta-analysis of 308-nm excimer laser therapy for alopecia areata.

Meta-analysis of 308-nm excimer laser therapy for alopecia areata. J Dermatolog Treat. 2019 Nov 12;:1-4 Authors: Gupta AK, Carviel JL Abstract Background: Alopecia areata (AA) is an autoimmune disease that can result in spontaneous hair loss. Currently, there is no US Food and Drug Administration (FDA) approved treatment, however new treatments are being investigated. Excimer laser and excimer lamp treatment have been suggested and have the benefit of mild/few adverse effects.Methods: A literature search and meta-analysis was performed to investigate the efficacy of the excimer laser and lamp for treatment of AA. Results: No controlled trials were found which utilized the 308-nm excimer lamp. Four controlled trials (N = 105) testing the efficacy of the 308-nm excimer laser were identified. When laser treatment was compared to control measured through the number of responders to treatment, the standardized mean difference was 18.37 (95% CI: 3.28, 102.77) in favor of treatment (p 
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research

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Alopecia areata is a common autoimmune disease, with a negative impact in health ‐related quality of life, especially when affecting children and adolescents. Current medical therapies, mainly for severe disease, are not effective (Semin Cut Med Surg, 2015; 34:72). There are no FDA (Food and Drug Administration) ‐ or ANVISA (Agência Nacional de Vigilância Sanitária)‐approved therapy for children with alopecia areata. JAK inhibitors are emerging as a promising therapy. AbstractAlopecia areata is a common autoimmune disease, with a negative impact in health ‐related quality of life, especially when...
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
Conclusions There was a significant relation between the severity of alopecia and treatment outcome. (p=0.038) Patients with alopecia areata had significantly better response when compared to alopecia totalis and universalis. There was no statistically significant relation with other parameters such as disease duration, age, gender, atopy history, age of onset, and histopathological features. PMID: 31655499 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
This article reviews the current literature and discusses the possible roles of vitamin D in the pathogenesis of alopecia areata in the context of (1) loss of immune privilege in hair follicle, (2) autoreactive effector T cells and mast cells, (3) nature killer group 2 member d-positive cytotoxic T cells, (4) Janus kinase/signal transducers and activators of transcriptional signaling pathway, (5) regulatory T cells, (6) immune checkpoints, and (7) oxidative stress, which are believed to play important roles in autoimmunity in AA. This paper provides new insights into research directions to elucidate the exact mechanisms of...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Kamila Migacz-Gruszka, Wojciech Branicki, Aleksander Obtulowicz, Magdalena Pirowska, Krystian Gruszka, Anna Wojas-PelcInternational Journal of Trichology 2019 11(5):185-188 The term “microbiome” defines the collective genome of all commensal, symbiotic, and pathogenic microbes living in the human body. The composition of microbiota in the gut and skin is influenced by many factors such as the stage of life, nutrition, lifestyle, and gender. In the past few years, several scientific papers have demonstrated an implication of microbiota in many immune-mediated diseases, for example, diabetes, ulcerative colitis,...
Source: International Journal of Trichology - Category: Dermatology Authors: Source Type: research
Autoimmune skin diseases are characterized by significant local and systemic inflammation that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway. Advanced understanding of this pathway has led to the development of targeted inhibitors of Janus kinases (JAKinibs). As a class, JAK inhibitors effectively treat a multitude of hematologic and inflammatory diseases. Growing evidence suggests that JAK inhibitors are efficacious in atopic dermatitis, alopecia areata, psoriasis, and vitiligo. Additional evidence suggests that JAK inhibition might be broadly useful in...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This article summarizes evidence-based treatment associated with expert-based recommendations. PMID: 31578836 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
CONCLUSION: Our data suggest that the CD2 may be a new therapeutic target for AAP. Further study is needed to explore the value of CD2 in the treatment of alopecia areata. PMID: 31558844 [PubMed - as supplied by publisher]
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research
Publication date: Available online 8 September 2019Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): M.S. Díaz, L. Morita, B. Ferrari, S. Sartori, M.F. Greco, L. Sobrevias Bonells, M.A. González-Enseñat, M.A. Vicente Villa, M. LarraldeAbstractLinear IgA bullous dermatosis is an acquired subepidermal immunoglobulin-mediated vesiculobullous disease. In this retrospective, observational, descriptive study, we describe the clinical characteristics, treatments, and outcomes of 17 patients with linear IgA bullous dermatosis. Two children had been vaccinated 2 weeks before the onset of sy...
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Alopecia areata (AA) is an organ-specific autoimmune disease resulting from the attack of hair follicle (HF) autoantigens through T-cell-mediated mechanism. Beyond the hypothesis of immune privilege collapse, we suppose any change of memory regulatory T cells (mTregs) affect the balance between effector T cell subsets in AA pathogenesis. CD49a expression defines different functional subsets in Trm cells, for examples, CD8+ CD49a+ Trm cells produce IFN- γ in vitiligo lesions, whereas CD8+CD49a- Trm cells produce IL-17 in psoriatic lesions.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive Immunity and Autoimmunity Source Type: research
Alopecia areata (AA) is regarded as an organ-specific and cell-mediated autoimmune disorder. In cytokine balance of AA, several reports have suggested AA as Th1 disease. For example, Murine IFN- γ-injected C3H/HeJ mice showed AA like hair loss with infiltration of CD4+and CD8+T cells Th1 cytokine. In human, IFN-γ-producing cells were detected in the perifollicular infiltrate, and serum Th1 cytokines were increased in AA patients. On the other hand, AA often complicates atopic dermatitis ( AD). However, the immunological aspects of AA with AD are still poorly understood.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Stem Cells, Skin Appendages and Tissue Regeneration Source Type: research
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