Effects of sodium thiosulfate (Na2S2O3) during resuscitation from hemorrhagic shock in swine with preexisting atherosclerosis

Publication date: Available online 14 November 2019Source: Pharmacological ResearchAuthor(s): Thomas Datzmann, Andrea Hoffmann, Oscar McCook, Tamara Merz, Ulrich Wachter, Jonathan Preuss, Sabine Vettorazzi, Enrico Calzia, Michael Gröger, Fabian Kohn, Andreas Schmid, Nicole Denoix, Peter Radermacher, Martin WeplerAbstractControversial data are available on hydrogen sulfide (H2S) during hemorrhage and resuscitation, depending on timing, dosing, mode of application, and the H2S donor used. Sodium thiosulfate (Na2S2O3) is a recognized drug devoid of major side effects, which attenuated murine acute lung injury and cerebral ischemia/reperfusion injury. Therefore, we tested the hypothesis whether Na2S2O3 would mitigate organ dysfunction in porcine hemorrhage-and-resuscitation. We studied animals with pre-existing coronary artery disease because of the reduced coronary arterial expression of the H2S producing enzyme cystathionine-γ-lyase (CSE) in this prospective, randomized, controlled, blinded experimental study.20 anesthetized and instrumented pigs underwent 3 hours of hemorrhage (removal of 30 % of the blood volume and subsequent titration of mean arterial pressure to 40 mmHg). Resuscitation (72 hours) comprised re-transfusion of shed blood, crystalloids, and continuous i.v. norepinephrine. Animals randomly received vehicle or Na2S2O3 (0.1 g·kg-1 h-1) for 24 hours.Before, at the end of and every 24 hours after sh...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research

Related Links:

Abstract Reactive oxygen species (ROS) are essential for cellular signaling and physiological function. An imbalance between ROS production and antioxidant protection results in a state of oxidative stress (OS), which is associated with perturbations in reduction/oxidation (redox) regulation, cellular dysfunction, organ failure, and disease. The pathophysiology of OS is closely interlinked with inflammation, mitochondrial dysfunction, and, in the case of surgery, ischemia/reperfusion injury (IRI). Perioperative OS is a complex response that involves patient, surgical, and anesthetic factors. The magnitude of tissu...
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
Conclusions: Recurrent AHCE should be taken seriously and managed with conventional work-up. If noninformative, genetic work-up should follow irrespective of the family history.
Source: Journal of Clinical Neuromuscular Disease - Category: Neurology Tags: Review Article Source Type: research
Abstract Reactive oxygen species (ROS) are essential for cellular signaling and physiological function. An imbalance between ROS production and antioxidant protection results in a state of oxidative stress (OS), which is associated with perturbations in reduction/oxidation (redox) regulation, cellular dysfunction, organ failure, and disease. The pathophysiology of OS is closely interlinked with inflammation, mitochondrial dysfunction, and, in the case of surgery, ischemia/reperfusion injury (IRI). Perioperative OS is a complex response that involves patient, surgical, and anesthetic factors. The magnitude of tissu...
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
Hyperoxia (ventilation with FIO2 = 1.0) has vasoconstrictor properties, in particular in the coronary vascular bed, and, hence, may promote cardiac dysfunction. However, we previously showed that hyperoxia attenuated myocardial injury during resuscitation from hemorrhage in swine with coronary artery disease. Therefore, we tested the hypothesis whether hyperoxia would also mitigate myocardial injury and improve heart function in the absence of chronic cardiovascular comorbidity. After 3 h of hemorrhage (removal of 30% of the calculated blood volume and subsequent titration of mean arterial pressure to 40 mm Hg) 19 a...
Source: Shock - Category: Emergency Medicine Tags: Online Articles Source Type: research
In this study, we further examined this process in vivo by using heterozygous PARG knockout mice (PARG+/−). Wild-type and PARG+/− mice were individually treated with 0 or 10 μg/m3 BaP for 90 or 180 days by dynamic inhalation exposure. Pathological analysis of lung tissues showed that, with extended exposure time, carcinogenesis and injury in the lungs of WT mice was progressively worse; however, the injury was minimal and carcinogenesis was not detected in the lungs of PARG+/− mice. These results indicate that PARG gene silencing protects mice against lung cancer induced by BaP inhalation exposure. Fur...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions: This study demonstrated that NAR targeted microglial NLRP3 inflammasome to protect DA neurons against LPS-induced neurotoxicity. These findings suggest NAR might hold a promising therapeutic potential for PD. Background Parkinson's disease (PD) is the second most prevalent central nervous system (CNS) degenerative disease. It is characterized by slow and progressive loss of dopamine (DA) neurons in the midbrain substantia nigra (SN) with the accumulation of α-synuclein in Lewy bodies and neuritis (1). Although the etiology of PD remains unclear, amounts of studies have suggested that neur...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Alessia Buso1†, Marina Comelli1†, Raffaella Picco1, Miriam Isola1, Benedetta Magnesa1, Rado Pišot2, Joern Rittweger3,4, Desy Salvadego1, Boštjan Šimunič2, Bruno Grassi1,5 and Irene Mavelli1,6* 1Department of Medicine, University of Udine, Udine, Italy 2Institute for Kinesiology Research, Science and Research Centre, Koper, Slovenia 3Department of Pediatrics and Adolescent Medicine, University of Cologne, Cologne, Germany 4Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany 5Institute of Bioimaging and Molecular Physiology, National Research Council...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusion: Using three different strategies to either prevent formation or enhance elimination of O2⋅_ during the post-asphyxial period, we saw both reduced leukocyte adherence and preserved BBB function with treatment. These findings suggest that agents which lower O2⋅_ in brain may be attractive new therapeutic interventions for the protection of the neonatal brain following asphyxia. Introduction Asphyxia is a relatively common source of neonatal brain damage (1), affecting ~2 in every 1,000 births (2). The hypoxic ischemia resulting from this oxygen deprivation can produce long-term sequelae, includi...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with FMT,...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Vinay Kumar1, Workineh Torben2, Joshua Mansfield3, Xavier Alvarez3, Curtis Vande Stouwe4, Jian Li5, Siddappa N. Byrareddy6, Peter J. Didier3, Bapi Pahar3, Patricia E. Molina4,7 and Mahesh Mohan3* 1Nektar Therapeutics, South San Francisco, CA, United States 2Department of Biological Sciences, LSU, Alexandria, LA, United States 3Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, United States 4Department of Physiology, LSUHSC, New Orleans, LA, United States 5Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
More News: Anesthesia | Anesthesiology | Cardiology | Drugs & Pharmacology | Heart | Liver | Mitochondrial Disease | Respiratory Medicine | Sodium | Study | Urology & Nephrology