Effects of sodium thiosulfate (Na2S2O3) during resuscitation from hemorrhagic shock in swine with preexisting atherosclerosis

Publication date: Available online 14 November 2019Source: Pharmacological ResearchAuthor(s): Thomas Datzmann, Andrea Hoffmann, Oscar McCook, Tamara Merz, Ulrich Wachter, Jonathan Preuss, Sabine Vettorazzi, Enrico Calzia, Michael Gröger, Fabian Kohn, Andreas Schmid, Nicole Denoix, Peter Radermacher, Martin WeplerAbstractControversial data are available on hydrogen sulfide (H2S) during hemorrhage and resuscitation, depending on timing, dosing, mode of application, and the H2S donor used. Sodium thiosulfate (Na2S2O3) is a recognized drug devoid of major side effects, which attenuated murine acute lung injury and cerebral ischemia/reperfusion injury. Therefore, we tested the hypothesis whether Na2S2O3 would mitigate organ dysfunction in porcine hemorrhage-and-resuscitation. We studied animals with pre-existing coronary artery disease because of the reduced coronary arterial expression of the H2S producing enzyme cystathionine-γ-lyase (CSE) in this prospective, randomized, controlled, blinded experimental study.20 anesthetized and instrumented pigs underwent 3 hours of hemorrhage (removal of 30 % of the blood volume and subsequent titration of mean arterial pressure to 40 mmHg). Resuscitation (72 hours) comprised re-transfusion of shed blood, crystalloids, and continuous i.v. norepinephrine. Animals randomly received vehicle or Na2S2O3 (0.1 g·kg-1 h-1) for 24 hours.Before, at the end of and every 24 hours after shock, hemodynamics, metabolism, blood gases, lung, ...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research