Variation in diagnostic NAFLD/NASH read-outs in paired liver samples from rodent models

DiscussionDependent on animal model, both histopathological and biochemical end-points differed between sampling sites in the liver. Based on these findings, we recommend that sample site location is highly standardized and properly reported in order to minimize potential sampling variation and to optimize reproducibility and meaningful comparisons of preclinical studies of NAFLD.
Source: Journal of Pharmacological and Toxicological Methods - Category: Drugs & Pharmacology Source Type: research

Related Links:

This study indicates that intestinal microbiota of human microbiota-associated mice inoculated with different fecal suspensions react to dietary quercetin in different ways. PMID: 31777425 [PubMed]
Source: Journal of Clinical Biochemistry and Nutrition - Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research
CONCLUSION: Gender, BMI, and HDL were found to be predictors of steatosis. Male patients with low HDL and high BMI are at greater risk of steatosis and should be carefully examined for the presence of NAFLD. PMID: 31754954 [PubMed - as supplied by publisher]
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
Authors: Yang F, Jia X, Lei P, He Y, Xiang Y, Jiao J, Zhou S, Qian W, Duan Q Abstract OBJECTIVE: To develop and test a novel method for automatic quantification of hepatic steatosis in histologic images based on the deep learning scheme designed to predict the fat ratio directly, which aims to improve accuracy in diagnosis of non-alcoholic fatty liver disease (NAFLD) with objective assessment of the severity of hepatic steatosis instead of subjective visual estimation. MATERIALS AND METHODS: Thirty-six 8-week old New Zealand white rabbits of both sexes were fed with high-cholesterol, high-fat diet and sacrifice...
Source: Journal of X-Ray Science and Technology - Category: Radiology Tags: J Xray Sci Technol Source Type: research
ConclusionThese findings indicate that CPT may exert the therapeutic effects on NAFLD via regulating PI3K/Akt/GSK3β pathway.Graphical Abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Conclusions/interpretationThese results indicate thatLight deficiency in HFHCD improves hepatic glucose tolerance, and reduces hepatic inflammation and NAFL. This is accompanied by decreased systemic inflammation and adipose tissue cytokine secretion and by changes in the expression of key genes such asKlf6 andTlr4 involved in NAFLD. These results suggest that therapies to block LIGHT-dependent signalling might be useful to restore hepatic homeostasis and to restrain NAFLD.
Source: Diabetologia - Category: Endocrinology Source Type: research
ConclusionThis is the first study demonstrating an improvement in disease activity in mice with advanced NASH with fibrosis by a diet containing Mastiha.
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Food & Function Source Type: research
Abstract Clinical and animal studies have reported an association between low birth weight and the development of non-alcoholic fatty liver disease (NAFLD) in offspring. Using a model of prenatal maternal 70% food restriction diet (FR30) in rat, we previously showed that maternal undernutrition predisposes offspring to altered lipid metabolism in adipose tissue, especially under high-fat (HF) diet. Here, using microarray-based expression profiling combined with metabolic, endocrine, biochemical, histological and lipidomic approaches, we assessed whether FR30 procedure sensitizes adult male offspring to impaired li...
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research
Conclusion: Pancreatic fat accumulation leads to worsening of pancreatic function which in turns exacerbates severity of metabolic syndrome associated with both, NAFLD and NAFPD. PMID: 31627351 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
This study aimed to investigate prevalence and risk factors of biopsy proven NAFLD in a cluster of healthy non-obese and lean individuals.Methods and MaterialsIn a retrospective study, adult (> 18 years) apparently healthy individuals who had donated liver to pediatric patients between July 2012 and October 2018 were included. Non-obese and lean individuals were defined as BMI 
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
CONCLUSION: In nondiabetic teetotallers dyslipidemias are the prime contributors to the development of NAFLD.RESUMO CONTEXTO: Os fatores de risco metab ólicos da doença hepática gordurosa não alcoólica (DHGNA) em abstêmios não diabéticos, que constituem um grupo distinto, não são bem definidos. OBJETIVO: Identificar os fatores de risco metabólicos da DHGNA em indivíduos não diabéticos e que não consumam álcool. MÉTODOS: Em um e studo transversal, o efeito dos parâmetros metabólicos (IMC, n&iacu...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
More News: Alcoholism | Cholesterol | Diets | Drugs & Pharmacology | Fatty Liver Disease (FLD) | Guinea Health | High Fat | Liver | Liver Disease | Non-alcoholic Fatty Liver Diseases (NAFLD) | Nutrition | Statistics | Study | Toxicology | Urology & Nephrology