Attenuation of adjuvant-induced arthrits by Stereospermum colais and Stereospermum suaveolens via modulation of inflammatory mediators

Publication date: Available online 14 November 2019Source: Journal of EthnopharmacologyAuthor(s): S. Latha, S. Seethalakshmi, D. Chamundeeswari, R. SenthamaraiAbstractEthnopharmacological relevanceThe plants selected for this study, Stereospermumcolais and Stereospermum suaveolens are named as Patala in Ayurvedic medicine. Patala is a component of the reputed dasamula (ten roots) used for various imperative ayurvedic formulations. The roots of Patala have rich traditional value especially in the treatment of inflammation and rheumatism. Nevertheless no methodical study has been consummated in these plants. Consequently, an endeavor to ascertain the anti-arthritic potential of the two plants was made besides to impart the fact with regards to the supreme one.Aim of the studyThe aim of the study is to evaluate the anti-arthritic potential of Stereospermum colais and Stereospermum suaveolens using Complete Freunds Adjuvant induced arthritic model.Materials and methodsThe freshly collected root material of Stereospermum colais (SC) and Stereospermum suaveolens (SS) were successively extracted with solvents such as petroleum ether, chloroform, ethyl acetate and ethanol by cold maceration and the ethanolic extracts of Stereospermum colais (EESC) and Stereospermum suaveolens (EESS) were used subjected to acute oral toxicity and in vivo anti-arthritic evaluation using Complete Freunds Adjuvant induced arthritic model using methotrexate as standard. Body weight changes, reduction in p...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research