Efficacy of antiviral treatment in cytomegalovirus detected ulcerative colitis: meta-analysis of available data.

Conclusions: Data produced in this study do not encourage ganciclovir treatment for UC patients. However, studies included in this analysis were observational, and thus, inherited severe selection bias. We suggest randomized controlled studies be conducted to make firm recommendations in this context. PMID: 31718340 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

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Authors: Maeda T, Sakai H, Ozawa N, Sugiyama T, Takada J, Kubota M, Ibuka T, Shirakami Y, Araki H, Shimizu M Abstract Cytomegalovirus (CMV) is a ubiquitous member of the Herpesviridae family that can present with a variety of clinical manifestations, including encephalitis, retinitis, interstitial pneumonia and colitis. These serious symptoms are generally observed as opportunistic infections in immunocompromised hosts, including patients with acquired immunodeficiency syndrome and those receiving steroids and/or immunosuppressants. Symptomatic CMV infections in patients with ulcerative colitis are found in patient...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Condition:   Ulcerative Colitis, Unspecified Intervention:   Drug: Valganciclovir Sponsors:   Centre Hospitalier Universitaire de Saint Etienne;   Ministry of Health, France Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Ulcerative Colitis, Unspecified Intervention:   Drug: Valganciclovir Sponsors:   Centre Hospitalier Universitaire de Saint Etienne;   Ministry of Health, France Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Ulcerative Colitis, Unspecified Intervention:   Drug: Valganciclovir Sponsors:   Centre Hospitalier Universitaire de Saint Etienne;   Ministry of Health, France Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Ulcerative Colitis, Unspecified Intervention:   Drug: Valganciclovir Sponsors:   Centre Hospitalier Universitaire de Saint Etienne;   Ministry of Health, France Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Ulcerative Colitis, Unspecified Intervention:   Drug: Valganciclovir Sponsors:   Centre Hospitalier Universitaire de Saint Etienne;   Ministry of Health, France Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Ulcerative Colitis, Unspecified Intervention:   Drug: Valganciclovir Sponsors:   Centre Hospitalier Universitaire de Saint Etienne;   Ministry of Health, France Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Ulcerative Colitis, Unspecified Intervention:   Drug: Valganciclovir Sponsors:   Centre Hospitalier Universitaire de Saint Etienne;   Ministry of Health, France Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Oh SJ, Lee CK, Kim YW, Jeong SJ, Park YM, Oh CH, Kim JW, Kim HJ Abstract Background and aims: The impact of cytomegalovirus (CMV) colitis on long-term outcomes of ulcerative colitis (UC) flares remains controversial. Methods: A total of 257 UC patients with moderate-to-severe flares were observed for a mean follow-up of 41.2 months. CMV colitis was defined as histopathologic confirmation of CMV inclusions obtained from macroscopic endoscopic lesions in patients with UC flares. An independent gastrointestinal pathologist prospectively reviewed all specimens. A poor outcome was defined as any of hospitalizat...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Condition:   Cytomegalovirus Infections Interventions:   Procedure: Biopsies;   Biological: Blood samples Sponsor:   Centre Hospitalier Universitaire de Saint Etienne Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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