Epidemiology of polycythemia vera in a Mexican population

In conclusion, epidemiology of PV in Mexican population is similar to that reported in Western studies, but with more venous thrombosis at diagnosis and a higher incidence of vascular complications postdiagnosis.
Source: Memo - Magazine of European Medical Oncology - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 6 March 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Onur Kirkizlar, Tugcan Alp Kirkizlar, Elif Gulsum Umit, Ismail Asker, Mehmet Baysal, Volkan Bas, Sedanur Karaman Gulsaran, Ufuk Demirci, Ahmet Muzaffer Demir
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Venous thromboembolic (VTE) events are associated with high morbidity and mortality in malignancy patients. We should be aware in terms of VTE in patients who has involvement of spleen, advanced stage disease or central venous line especially initial high fibrinogen levels even if in a good performance status.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
ash;rensen The major complications of Philadelphia-negative (Ph-Negative) myeloproliferative neoplasms (MPNs) are thrombosis, haemorrhage and leukemic transformation. As systemic and haematological diseases, MPNs have the potential to affect many tissues and organs. Some complications lead to the diagnosis of MPNs, but other signs and symptoms are often misdiagnosed or neglected as a sign of MPN disease. Therefore, we reviewed the current literature to investigate and delineate the clinical manifestations seen in the eyes of Ph-negative MPN patients. We found that ocular manifestations are common among patients with MP...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
PMID: 32101474 [PubMed - in process]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
AbstractPatients with polycythemia vera (PV) or essential thrombocythemia (ET) presenting with splanchnic vein thrombosis (SVT) might have a specific clinico-biological profile. To investigate this hypothesis, 3705 PV/ET patients from three national registers, 118 of them presenting with SVT, were reviewed. After correction for age and sex, PV/ET patients with SVT showed an increased risk of death (HR 2.47, 95% CI 1.5 –4.01,p 
Source: Annals of Hematology - Category: Hematology Source Type: research
Acute Lymphoblastic Leukemia (ALL) is the commonest malignancy in childhood with a second incidence peak in adulthood. Improvements in pediatric therapy including the addition of L-asparaginase (L-ASP) have enabled cure rates in excess of 90% to be achieved in children. More recently L-ASP-containing pediatric protocols are being used to treat younger adults with ALL and have improved survival by approximately 2-fold. However, a toxicity associated with L-ASP-containing therapy in ALL is venous thromboembolism (VTE) which is associated with significant morbidity in this patient population and results in interruptions in L-...
Source: Thrombosis Research - Category: Hematology Authors: Tags: Short Review Source Type: research
to “Incidence of Silent Thrombosis in Patients Younger Than 60 Years With Myeloproliferative Neoplasms: Single-Center Egyptian Study” [Clin Lymphoma Myeloma Leuk. 2019 Aug;19(8):e425-429]
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Tags: Corrigendum Source Type: research
Thrombotic Microangiopathy (TMA) is a group of disorders characterized by endothelial injury leading to activation of coagulation cascade, consumptive coagulopathy, thrombocytopenia and hemolytic anemia. TMA causes end organ damage such as renal and central nervous system dysfunction related to small vessel thrombosis and resultant ischemia (1). The pathogenesis of TMA is primarily divided into four major pathways a) autoantibody against ADAMTS13 leading to TTP (thrombotic thrombocytopenic purpura), b) atypical HUS (hemolytic uremic syndrome) mediated by complement activation related to inherited mutations in the complemen...
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
Thrombotic microangiopathy (TMA) is a group of disorders characterized by endothelial injury, leading to activation of coagulation cascade, consumptive coagulopathy, thrombocytopenia, and hemolytic anemia. TMA causes end-organ damage such as renal and central nervous system dysfunction related to small vessel thrombosis and resultant ischemia.1 The pathogenesis of TMA is primarily divided into 4 major pathways: (1) autoantibody against ADAMTS13 leading to thrombotic thrombocytopenic purpura (TTP); (2) atypical hemolytic uremic syndrome (HUS) mediated by complement activation related to inherited mutations in the complement...
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
Abstract Venous thromboembolism is a common complication of asparaginase-based chemotherapy regimens for the treatment of acute lymphoblastic leukemia. Thrombosis associated with asparaginase administration poses a number of specific and often clinically challenging management decisions. This review provides guidance on the prevention and treatment of thrombosis associated with asparaginase in adults including discussions on antithrombin repletion, pharmacologic thromboprophylaxis, cerebral venous thrombosis, and therapeutic anticoagulation. PMID: 31999063 [PubMed - in process]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: J Thromb Haemost Source Type: research
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