Eliminating common bacterial infection significantly decreases gastric cancer risk

(University of Pennsylvania School of Medicine) Penn researchers are first to assess Helicobacter pylori infection and gastric cancer risk in Americans, certain demographics and ethnic groups.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Successfully eliminating  Helicobacter pylori from a patient’s gastrointestinal tract could lead to a significant decrease in gastric cancer risk.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Alaska Native (AN) people experience higher incidence of, and mortality from, gastric cancer compared to other U.S. populations1, 2. Compared to the general U.S. population, gastric cancer in AN people occurs at a younger age, is diagnosed at later stages, is more evenly distributed between the sexes, and is more frequently signet-ring or diffuse histology3. It is known that the prevalence of Helicobacter pylori (Hp) infection, a risk factor for gastric cancer, is high in AN people4; however, high antimicrobial resistance combined with high reinfection rates in Alaska make treatment at the population level complex5.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
In the original publication of the article, the figure  3 was published with errors. The corrected figure 3 should appear as in this correction.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Cochrane China Network working groups had an informal meeting included in the 13th China Health Technology Assessment Forum, hosted by Prof Yingyao Chen (from Fudan University) on 17th November.Eight Cochrane China Network working groups reported their work on Cochrane and some achievements in health technology assessment Cochrane. Prof Jianping Liu (Beijing University of Chinese medicine) gave the opening session, and introduced Cochrane China network and the whole session.Prof Shiyao Chen, from Zhongshan hospital affiliated to Fudan University, talked about “The clinical decision on screening helicobacter pylori fo...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
Authors: Zhang F, Chen C, Hu J, Su R, Zhang J, Han Z, Chen H, Li Y Abstract Helicobacter pylori (H. pylori) is a gram-negative pathogen that colonizes gastric epithelial cells. The drug resistance rates of H. pylori have dramatically increased, causing persistent infections. Chronic infection by H. pylori is a critical cause of gastritis, peptic ulcers and even gastric cancer. In host cells, autophagy is stimulated to maintain cellular homeostasis following intracellular pathogen recognition by the innate immune defense system. However, H. pylori-induced autophagy is not consistent during acute and chronic infectio...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Abstract Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via the bacterial type IV secretion system. Delivered CagA then undergoes tyrosine phosphorylation at the Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs in its C-terminal region and acts as an oncogenic scaffold protein that physically interacts with multiple host signaling proteins in both tyrosine phosphorylation-dependent and -independent manners. Analysis of CagA using in vitro cultured gastric epithelial cells has indicated that ...
Source: Cellular and Molecular Immunology - Category: Molecular Biology Authors: Tags: Cell Mol Immunol Source Type: research
Conclusions: This study suggests a synergistic interaction betweenH. pyloriinfection, especiallycagA-positiveH. pylori,andPro/Pro genotype ofTP53 codon 72 polymorphism might play a significant role in the pathogenesis of GC in the Vietnamese population.
Source: The Journal of Infection in Developing Countries - Category: Infectious Diseases Source Type: research
ABSTRACT BACKGROUND: Helicobacter pylori infection is the most important risk factor for gastric atrophy and intestinal metaplasia, both considered gastric cancer precursor lesions. Therefore, the investigation of the occurrence of H. pylori infection, precursor lesions and associated factors guides the adoption of specific strategies for the control this type of cancer. OBJECTIVE: To evaluate the prevalence of H. pylori infection in patients undergoing upper digestive endoscopy, as well as the prevalence of intestinal metaplasia, atrophy and chronic inflammation and their association with H. pylori infection. METHODS: A r...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
CONCLUSION: All the three methods have high accuracy for the diagnosis of H. pylori infection in the Vietnamese population with gastritis and gastric ulcers. These tests can be employed in the clinical settings for the Vietnamese population. CLO test should be used in combination with the other tests to reduce false-negative results. PMID: 31759377 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Conclusion &Impact: H. pylori was found in tap-water samples, however, detection rates were lower than in gastric cancer samples. Other sources of infection transmission should be investigated. PMID: 31759341 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
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