A Randomized Trial to Evaluate the Effects of Folic Acid and Zinc Supplementation on Male Fertility and Live Birth: Design and Baseline Characteristics.

A Randomized Trial to Evaluate the Effects of Folic Acid and Zinc Supplementation on Male Fertility and Live Birth: Design and Baseline Characteristics. Am J Epidemiol. 2019 Nov 12;: Authors: Schisterman EF, Clemons T, Peterson CM, Johnstone E, Hammoud AO, Lamb D, Carrell DT, Perkins NJ, Sjaarda LA, Van Voorhis BJ, Ryan G, Summers K, Campbell B, Robins J, Chaney K, Mills JL, Mendola P, Chen Z, DeVilbiss EA, Mumford SL Abstract The Folic Acid and Zinc Supplementation Trial (FAZST) was a multi-center, double-blind, block-randomized, placebo-controlled trial to determine whether folic acid and zinc supplementation in men improves semen quality and increases live birth rate among couples seeking infertility treatment (2013-2017). Eligible men were ages 18 years or older with their female partners ages 18-45 seeking infertility treatment. Men were randomized (1:1) to 5 mg folic acid and 30 mg elemental zinc daily or matching placebo for six months. Randomization was stratified by site and intended infertility treatment (in vitro fertilization (IVF), non-IVF/study site, and non-IVF/outside clinic). Follow-up of men continued for 6 months, while female partners were passively followed for a minimum of nine months. Women who conceived were followed throughout pregnancy. Overall, 2,370 men were randomized between 2013-2017 (1185 folic acid and zinc, 1185 placebo), with mean age of 33 years and body mass index of 29.8. Participants were mostly white (82%), well-ed...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research

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Purpose of review The sensitivity of semen analysis for detection of infertility remains low. Many factors not measured in traditional semen analysis may contribute to male factor infertility. DNA fragmentation, oxidative stress, and sperm aneuploidy are three factors that may contribute further information to the evaluation when semen analysis is inconclusive. Recent findings DNA fragmentation measures the destruction of and failure to repair damage to DNA. Increased DNA fragmentation has been used as a marker for oxidative stress as well as toxic exposure. The oxidative stress adduct measures DNA aberrations, which ...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: GENDER MEDICINE, INFERTILITY AND ERECTILE FUNCTION: Edited by Ryan Flannigan and Ranjith Ramasamy Source Type: research
ConclusionsThis is the first report of livebirth after use of robotic ‐assisted laparoscopy in uterus transplantation and is thereby a proof‐of‐concept of use of minimal invasive surgery in this new type of transplantation.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Many papers and reviews have described the changes of the cervix during pregnancy, cervical cancer, sexually transmitted infections, and cervicovaginal microbiota. In this Views and Reviews, we focus on some specific topics in relation to the uterine cervix and infertility: early cervical cancer and fertility sparing surgery, cesarean scar defect, cervical incompetence, and cervical m üllerian anomalies.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Views and reviews Source Type: research
Around 20% of pregnant women undergo cesarean section (CS), and in most regions of the world CS rates continue to grow. There is still no clear definition of what is considered a normal physiologic aspect of a CS scar and what is abnormal. Cesarean scar defects (CSDs) should be suspected in women presenting with spotting, dysmenorrhea, pelvic pain, or infertility and a history of CS. CSDs can be visualized with the use of hysterosalpingography, transvaginal sonography, saline infusion sonohysterography, hysteroscopy, and magnetic resonance imaging.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Views and reviews Source Type: research
Conclusion: HIFU showed a safe and effective profile as a therapeutic management option for patients with adenomyosis. In comparison with LE, HIFU treatment achieved better postoperative reproductive outcomes. HIFU treatment should be encouraged and implemented in clinical practice. PMID: 32208771 [PubMed - in process]
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
If you ’ve had to cancel a fertility treatment because of coronavirus, we’d like to hear from you. Please fill out this form.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus (2019-nCoV) Infertility Egg Donation and Freezing Pregnancy and Childbirth Fertility Drugs Parenting American Society for Reproductive Medicine Source Type: news
I was diagnosed with anorexia nervosa over a decade ago. Blinded by the eating disorder to the damage that was occurring both internally and externally, the possibility of infertility did not occur to me. When I married at 21, my husband and I both dreamed of one day becoming parents and I lived in this optimism for some time. However, after my periods stopped for 7 years, I began to doubt if being a mother would ever be my reality.  As an eating disorder patient, I had been regularly informed of the risk factors of my illness, some of which included amenorrhoea, the absence of menstruation, and a high chance of infer...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anorexia Eating Disorders Personal Pregnancy Infertility Source Type: blogs
Abstract To compare the ovarian responses after administration of two recombinant follicle-stimulating hormone (r-FSH) preparations under gonadotropin-releasing hormone (GnRH) analogue downregulation, we conducted a phase 3, randomized, multicenter, assessor-blind, active-controlled, parallel group study. The primary outcome was the number of oocytes retrieved. The secondary outcomes included total dose and duration of r-FSH administered, oocyte quality, blood estradiol levels, follicular development, fertilization rates, implantation rates, and pregnancy rates (biochemical, clinical, and ongoing). A total of 451 ...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
AbstractAssisted reproductive technologies (ART) represent commonly utilized management strategies for infertility with multifactorial causes (including genetically predisposed diseases). Amongst ART, in vitro fertilization (IVF) is the most popular. IVF treatment may predispose the mother to increased risks and complications during pregnancy, and there may be adverse fetal outcomes. Hormonal therapies, including oral contraceptives, may impair glucose and lipid metabolism, and promote insulin resistance and inflammation. IVF treatment involves administration of reproductive hormones, similar in composition but in much hig...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
ConclusionsClinical pregnancy rate and live birth rates after COS-IUIs were significantly influenced by female age and FSH levels.Trial registrationClinical trial registration number: NCT03836118
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
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