Vitamin E Loaded Naringenin Nanoemulsion via Intranasal Delivery for the Management of Oxidative Stress in a 6-OHDA Parkinson's Disease Model.

Conclusion: Encouraging results from current study provide evidence for possible efficacy of a novel noninvasive intranasal delivery system of NRG for management of PD related symptoms. PMID: 31111044 [PubMed - indexed for MEDLINE]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research

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Condition:   Parkinson Disease Intervention:   Other: Non pharmacological therapy Sponsor:   Puerta de Hierro University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Neurological diseases particularly Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and epilepsy are on the rise all around the world causing morbidity and mortality globally with a common symptom of gradual loss or impairment of motor behaviour. Striatum, which is a component of the basal ganglia, is involved in facilitating voluntary movement while the cerebellum is involved in the maintenance of balance and coordination of voluntary movements. Dopamine, serotonin, gamma-aminobutyric acid (GABA), and glutamate, to name a few, interact in regulating the excitation and inhibition of motor neuro...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Sensors, Vol. 19, Pages 5468: Cueing Paradigms to Improve Gait and Posture in Parkinson’s Disease: A Narrative Review Sensors doi: 10.3390/s19245468 Authors: Niveditha Muthukrishnan James J. Abbas Holly A. Shill Narayanan Krishnamurthi Progressive gait dysfunction is one of the primary motor symptoms in people with Parkinson’s disease (PD). It is generally expressed as reduced step length and gait speed and as increased variability in step time and step length. People with PD also exhibit stooped posture which disrupts gait and impedes social interaction. The gait and posture impairments are u...
Source: Sensors - Category: Biotechnology Authors: Tags: Review Source Type: research
Sensors, Vol. 19, Pages 5465: Wearable Electronics Assess the Effectiveness of Transcranial Direct Current Stimulation on Balance and Gait in Parkinson’s Disease Patients Sensors doi: 10.3390/s19245465 Authors: Mariachiara Ricci Giulia Di Lazzaro Antonio Pisani Simona Scalise Mohammad Alwardat Chiara Salimei Franco Giannini Giovanni Saggio Currently, clinical evaluation represents the primary outcome measure in Parkinson’s disease (PD). However, clinical evaluation may underscore some subtle motor impairments, hidden from the visual inspection of examiners. Technology-based objective m...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
AbstractParkinson ’s disease (PD) is a slowly progressive geriatric disease, which can be one of the leading causes of serious socioeconomic burden in the aging society. Clinical trials suggest that prompt treatment of early-stage Parkinson’s disease (EPD) may slow down the disease progress and have a better resp onse. Therefore, conducting proteomics study to identify biomarkers for the diagnosis and disease-modifying therapies of EPD is vital. We aimed at identifying distinct protein autoantibody biomarkers of EPD by using the database of GSE62283 based on the platform GPL13669 downloaded from Gene Express io...
Source: Neurological Sciences - Category: Neurology Source Type: research
In this study, we investigated the effect of long-term 30% CR compared with ad libitum (AL) feeding on the microbiome in aging. We studied the Tg2576 model, where a mutant variant of the human APP is expressed in transgenic mice. This transgene results in cerebral amyloid accumulation, synaptic loss, and cognitive impairment by 12 months of age. We found that female Tg2576 mice have more substantial age-related microbiome changes compared to wildtype (WT) mice, including an increase in Bacteroides, which were normalized by CR. Specific gut microbiota changes were linked to Aβ levels, with greater effects in females th...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Condition:   Parkinson Disease Interventions:   Drug: CVN424 Low Dose;   Drug: CVN424 High Dose;   Drug: Placebo Sponsor:   Cerevance Beta, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: rTMS over M1 is useful for motor function and may have a small positive effect on cognition. However, better approaches for the latter are necessary, may be require multisite rTMS to target both motor and frontal cortical region. PMID: 31815705 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research
ConclusionThe present study demonstrated abnormal spontaneous synchrony in the left insula and left precuneus in patients with PD-MCI compared to PD-NC, which might provide a novel insight into the diagnosis and clinical treatment of cognitive impairment in PD.
Source: Neuroradiology - Category: Radiology Source Type: research
Conclusions: This review summarizes a model of microbiota-gut-brain-axis regulation of neuroinflammation in PD including several new mechanisms. We conclude with the need for clinical trials in PD patients to test this model for beneficial effects of Mediterranean based high fiber diets.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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