A severe form of epilepsy could be treated with cholesterol medication

A build-up of cholesterol in the brains of people with a severe form of epilepsy can cause prolonged seizures, but it may be possible to treat this with statins
Source: New Scientist - Health - Category: Consumer Health News Source Type: research

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ConclusionsStatin treatment, especially with intensive-dose statins, can reduce the risk of PSS. In addition, the risk of developing PSE appears to be significantly lower for prolonged statin treatment. However, due to the observational nature of this study, more investigations are warranted to confirm its findings.
Source: Seizure - Category: Neurology Source Type: research
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and neu...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
r W Abstract A variety of acute brain insults can induce epileptogenesis, a complex process that results in acquired epilepsy. Despite advances in understanding mechanisms of epileptogenesis, there is currently no approved treatment that prevents the development or progression of epilepsy in patients at risk. The current concept of epileptogenesis assumes a window of opportunity following acute brain insults that allows intervention with preventive treatment. Recent results suggest that injury-induced epileptogenesis can be a much more rapid process than previously thought, suggesting that the 'therapeutic window'...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Neuropharmacology Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Management of epilepsy usually involves the long-term use of antiepileptic drugs (AEDs) and a substantial percentage of patients require polytherapy to control their seizures [1]. The use of multiple AEDs poses a risk of drug interactions including enzyme induction or inhibition, alterations in protein-binding and expression of transporter proteins [2]. It may result in decreased efficacy or increased toxicity of AEDs. The use of some older AEDs (e.g. carbamazepine or phenytoin), known as potent hepatic enzyme-inducers is a major source of pharmacokinetic interactions between AEDs and other medications commonly used in eld...
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
CONCLUSION: Overall, the results of this study showed that lovastatin attenuates hippocampal cell death in Pilocarpine-induced status epilepticus rat model through downregulation of the pro-apoptotic Mst1 gene. ABBREVIATIONS: Mst1: Mammalian sterile 20-like kinase 1; Nrf2: nuclear factor erythroid 2-related factor 2; Bcl-2: B-cell lymphoma 2; HMG-CoA: 3-hydroxy-3-methylglutaryl-coenzyme A; RT-PCR: reverse transcription-polymerase chain reaction; TLE: Temporal Lobe Epilepsy; SE: status epilepticus. PMID: 30048231 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
British Journal of Clinical Pharmacology, EarlyView.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
AbstractBackgroundStatins possess neuroprotective effects. However, real-world evidence supporting their utility in post-stroke epilepsy (PSE) prevention is limited.ObjectiveThe association between statin use, including timing of prescribing (pre-stroke vs post-stroke), type (lipophilicity, intensity of therapy) and dose intensity, and risk of developing PSE were investigated by studying Taiwanese health claims (2003 –2013).MethodsPatients with new-onset ischaemic stroke were identified. The main outcome was a diagnosis of epilepsy after ischaemic stroke. According to pre-stroke statin use, groups of current users, f...
Source: CNS Drugs - Category: Neurology Source Type: research
CONCLUSIONS: This study did not demonstrate a significant beneficial or deleterious effect of statin use on risk of being diagnosed with epilepsy. Clinicians should not withhold statins, whenever indicated, in patients with epilepsy. PMID: 29400081 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - Category: Drugs & Pharmacology Authors: Tags: Ann Pharmacother Source Type: research
Publication date: January 2018 Source:Epilepsy & Behavior, Volume 78 Author(s): Clarissa Vasconcelos de Oliveira, Jéssica Grigoletto, Julia Marion Canzian, Marta Maria Medeiros Frescura Duarte, Thiago Duarte, Ana Flávia Furian, Mauro Schneider Oliveira Temporal lobe epilepsy (TLE) is the most frequent and medically refractory type of epilepsy in humans. In addition to seizures, patients with TLE suffer from behavioral alterations and cognitive deficits. Poststatus epilepticus model of TLE induced by pilocarpine in rodents has enhanced the understanding of the processes leading to epilepsy and thus, of po...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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