26 infants may have been exposed to tuberculosis at Washington hospital

MultiCare Auburn Medical Center in Washington is notifying the workers, patients and their families that a hospital employee may have exposed them to tuberculosis between April and September.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Authors: Torres M, Herrera MT, Fabián-San-Miguel G, Gonzalez Y Abstract Diabetes mellitus, a metabolic disease characterized by hyperglycemia and poor glucose control, is a risk factor for Mycobacterium tuberculosis (M. tuberculosis) infection and the development of active tuberculosis. To evaluate whether M. tuberculosis infection susceptibility is associated with an intrinsic factor in monocytes from type 2 diabetes (T2D) patients or it is associated with hyperglycemia per se, we analyzed TLR-2 and TLR-4 expression by flow cytometry and the cytokines IL-1β, IL-6, IL-8, IL-10, and TNF-α by cytome...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Publication date: Available online 10 December 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Ambuj Kumar Kushwaha, Shashi BhushanAbstractProtein synthesis in all the living cells is mediated by a large protein-RNA complex called the ribosome. These macromolecular complexes can range from 2.5 (prokaryotes) to 4.2 MDa(eukaryotes) in size and undergo various conformational transitions during protein synthesis to translate the genetic code into the nascent polypeptide chains. Recent advances in cryo-electron microscopy (cryo-EM) and image processing methods have provided numerous detailed structures of rib...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
We report a middle aged man who was admitted with severe necrotising fasciitis following a motor vehicle accident (MVA). Histopathology of the excised tissue suggested mucormycosis while a bone tissue culture revealed fully sensitive Mycobacterium tuberculosis. He received intravenous liposomal amphotericin B combined with multiple surgical debridements and ended with right shoulder disarticulation. In addition he completed a nine months course of anti-tuberculosis treatment. He remained stable one year following his admission.We believe that trauma contributed to both conditions by direct inoculation of fungal spores and ...
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
CONCLUSIONS: In this large, international cohort of people living with HIV-associated TB in LMIC who received intensive phase DOT, DOT during the continuation phase of anti-TB therapy was not associated with a decreased odds of unfavourable TB treatment outcomes compared to SAT. Randomized trials evaluating the effect of continuation-phase DOT on TB outcomes among PLHIV are needed. PMID: 31814312 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
This airborne infectious disease is believed to be more than 3 million years old. Here's what you need to know.
Source: Nursing Made Incredibly Easy - Category: Nursing Tags: Feature Source Type: research
Contributors : Tingting Chen ; Caroline Blanc ; Maju Joe ; Todd L Lowary ; Jacqueline M AchkarSeries Type : Protein profiling by protein arrayOrganism : Homo sapiensIncreasing evidence suggests that antibodies (Abs) can have protective roles in M. tuberculosis (Mtb) infection but knowledge of the most relevant protective antigens and epitopes in humans is limited.Using novel glycan arrays, we establish that human serum IgG induced against the M. tuberculosis (Mtb) capsular polysacharide arabinomannan (AM) in natural Mtb infection is highly heterogeneous in its binding specificity and differs in both its reactivity to oligo...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Protein profiling by protein array Homo sapiens Source Type: research
In this study, monocytes were trained with beta-glucan and then re-exposed to Mycobacterium tuberculosis.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Publication date: Available online 9 December 2019Source: Microbiological ResearchAuthor(s): Vivek Vinod, Sukhithasri Vijayrajratnam, Anil Kumar Vasudevan, Raja BiswasAbstractBacterial cell surface adhesins play a major role in facilitating host colonization and subsequent establishment of infection. The surface of Mycobacterium tuberculosis, owing to the complex architecture of its cell envelope, expresses numerous adhesins with varied chemical nature, including proteins, lipids, lipoproteins, glycoproteins and glycopolymers. Studies on mycobacterial adhesins show that they bind with multifarious host receptors and extrac...
Source: Microbiological Research - Category: Infectious Diseases Source Type: research
Abstract This paper presents the first comprehensive report on traditional uses of medicinal shrubs of Rawalakot city, district Poonch, Azad Jammu and Kashmir, Pakistan. Ethobotanical data obtained from 120 informants were analyzed by relative frequency citation, use value, family use value, informant consensus factor, fidelity level and Jaccard index. In total, 41 shrubs belonging to 24 families and 34 genera were documented. Rosaceae was reported the most dominant family in the area (six species) and Berberidaceae showed maximum family use value (0.68). Leaves (35%) and fruits (33%) were the most commonly used plant part...
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
Ligands of the receptor for advanced glycation end products (RAGE) are key signalling molecules in the innate immune system but their role in tuberculosis-diabetes comorbidity (TB-DM) has not been investigated.
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
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