Giant parathyroid adenoma: a case report and review of the literature

ConclusionsGiant parathyroid adenoma is a rare cause of primary hyperparathyroidism and usually presents symptomatically  with high calcium and parathyroid hormone levels. Giant parathyroid adenoma is diagnosed by imaging and laboratory studies. Management is typically surgical, aiming at complete resection. Patients usually recover with no long-term complications or recurrence.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research

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This article describes the current diagnostic imaging approaches used in reptile medicine for evaluation of urinary tract disease. The use of radiographs, ultrasonography, computed tomography, MRI, and endoscopy is discussed and compared for the evaluation of urinary tract disease in reptiles.
Source: Veterinary Clinics of North America: Exotic Animal Practice - Category: Veterinary Research Authors: Source Type: research
CONCLUSION: Parathyroidectomy provided more BMD gain in the lumbar spine and femoral neck in patients with symptomatic PHPT when compared to patients with asymptomatic PHPT 1-year after parathyroidectomy. PMID: 31655512 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
AbstractFamilial hypocalciuric hypercalcemia (FHH) is a benign autosomal dominant condition characterized by lifelong asymptomatic hypercalcemia. FHH is typically caused by a heterozygous inactivating mutation of the calcium-sensing receptor (CaSR) and characterized by moderate hypercalcemia, inappropriately normal or elevated serum parathyroid hormone (PTH), and relative hypocalciuria (FeCa  2%. PTH levels were repeatedly below the mean of the reference range (on two separate assays) and sometimes even below the lower reference limit. Two siblings, one niece, and her son had hypercalcemia without nephrolithiasis. C...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Authors: Imam TH, Patail H, Patail H Abstract Medullary Sponge Kidney (MSK) disease is a rare congenital malformation of the distal nephron where cystic dilatation is appreciable in the collecting ducts and renal papillae. Most cases of the malformation are thought to arise from a malfunction within neurotrophic factor and tyrosine kinase interactions. Presentation and prognosis are usually indolent; however, they include urinary tract infections (UTI), nephrolithiasis and nephrocalcinosis, distal renal tubular acidosis (dRTA) and hypocitraturia. With an insidious and asymptomatic onset, MSK is a difficult renal ma...
Source: International Journal of Nephrology and Renovascular Disease - Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research
Conclusions: Parathyroidectomy in primary hyperparathyroidism during pregnancy is safe. PMID: 31501633 [PubMed - in process]
Source: Cirugia y Cirujanos - Category: Surgery Authors: Tags: Cir Cir Source Type: research
When the National Institutes of Health convened the first workshop devoted to the diagnosis and management of primary hyperparathyroidism (pHPT) in 1990, astute clinicians had already appreciated that the classic presentation of this disorder, established decades before as symptomatic and progressive, was no longer the typical face of the disease. Primary hyperparathyroidism was being diagnosed with increasing frequency in asymptomatic patients and those for whom reduced bone mass was the main clinical finding. Guidelines published in 1991 from that first National Institutes of Health conference outlined the diagnostic cri...
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
Stone disease has plagued humanity since ancient times. Kidney stones have been identified in Egyptian mummies. The Hippocratic oath describes their treatment: “I will not use the knife, not even verily, on sufferers from stone, but I will give place to such as are craftsmen therein.” Who gets kidney stones and why? The lifetime risk of kidney stones among adults in the US is approximately 9%, and it appears that global warming may be increasing that risk. (As the climate warms, human beings are more likely to get dehydrated, which increases the risk of stone formation.) There are four major types of kidney sto...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Healthy Aging Kidney and urinary tract Source Type: blogs
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Parathyroid hormone levels of patients with primary hyperparathyroidism are not predictive of kidney stones or low bone density, according to research published inThe Journal of Clinical Endocrinology& Metabolism.Healio
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Abstract CONTEXT: Primary Hyperparathyroidism (PHPT) has a prevalence of 0.86% and is associated with increased risk of nephrolithiasis and osteoporosis. PHPT may also be associated with an increased risk of cardiovascular disease and mortality. OBJECTIVE: To identify risk factors for nephrolithiasis, osteoporosis and mortality in PHPT. DESIGN: Retrospective cohort study. SETTING: University teaching hospital. PATIENTS: PHPT presenting between 2006 - 2014 (n = 611). MAIN OUTCOME MEASURES: Assessment of nephrolithiasis, osteoporosis and mortality. RESULTS: 13.9% of PHPT patients had ne...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
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