Identification of Acute Pancreatitis-Related Genes and Pathways by Integrated Bioinformatics Analysis

ConclusionsThe study suggested that hub genes EGFR, CDH1, ACTB, CD44, and VCL may play vital role in the pathogenesis of acute pancreatitis and may serve as potential biomarkers to facilitate future acute pancreatitis diagnosis and treatment.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research

Related Links:

This article presents a unique 3D biocompatible Aluminum-based quantum structure (QS) for in vitro cancer detection using Surface Enhanced Raman Scattering (SERS). The Al-based QSs fabricated using ultrashort pulsed laser are of two distinct surface characters, wrinkled and smooth spherical. The limit of detection for chemical sensing of Crystal Violet and Rhodamine 6G by the Al-QS was driven up to single molecule sensing (femtomolar concentration). Biological sensing of cysteine, a disease biomarker and carcinoembryonic antigen (CEA), a cancer biomarker was also tested by the Al-QS. The ability of in vitro cell detection ...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
In this study, four different weight% of Punica granatum fruit peel extract were used as green stabilizers to synthesize IONPs followed by a series of characterization experiments and in vitro anticancer evaluation. Results revealed that all synthesized IONPs have high degree of crystallinity and purity. The optimum saturation magnetization, and hydrodynamic size were found to be ∼69 emu.g−1, and 26.52 nm, respectively. Morphological studies demonstrated that adding peel extract decreased size of NPs with the average particle size below 11 nm. Cytotoxicity assay showed that the IONPs were not react...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: 15 March 2020Source: Journal of Molecular Structure, Volume 1204Author(s): A.D. Herrera-España, J. Us-Martín, S. Hernández-Ortega, G. Mirón-López, L. Quijano, J.R. Villanueva-Toledo, G.J. Mena-RejónAbstractThe structural modification of natural products has shown to be a remarkable tool in the generation of novel bioactive molecules. Herein, the synthesis, structural analysis and anticancer activity of the novel triterpenoid thiazole 3 is reported. The synthesis was carried out through the bromination of ochraceolide A (1) and the subsequent heterocyclic condensat...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 14 December 2019Source: Chemico-Biological InteractionsAuthor(s): Ryan N. Serio, Lorraine J. GudasAbstractEthanol (EtOH) is a recreationally ingested compound that is both teratogenic and carcinogenic in humans. Because of its abundant consumption worldwide and the vital role of stem cells in the formation of birth defects and cancers, delineating the effects of EtOH on stem cell function is currently an active and urgent pursuit of scientific investigation to explicate some of the mechanisms contributing to EtOH toxicity. Stem cells represent a primordial, undifferentiated phase of devel...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 14 December 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Xinxin Shi, Yalei Hu, Hong-Min Meng, Jie Yang, Lingbo Qu, Xiao-Bing Zhang, Zhaohui LiAbstractIntracellular polarity has a large impact on the activity of a series of biomolecules or maintain the function of particular domains. Therefore, monitoring the changing of intracellular polarity can great improve the understanding its functions in living cell level. Herein, by employing p-phenylenediamine as precursor, we prepared a red emissive carbon dots based nanoprobe for real-time sensing polarity in living cells. With the i...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Conclusions This review describes how leukocyte-heparanase can be a double-edged sword in tumor progression; it can enhance tumor immune surveillance and tumor cell clearance, but also promote tumor survival and growth. We also discuss the potential of using heparanase in leukocyte therapies against tumors, and the effects of heparanase inhibitors on tumor progression and immunity. We are just beginning to understand the influence of heparanase on a pro/anti-tumor immune response, and there are still many questions to answer. How do the pro/anti-tumorigenic effects of heparanase differ across different cancer types? Does...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In this study, all tumors were adenocarcinomas that originate from ducts or ductules but infiltrate to involve all components of the pancreas. Other tumors that originate in pancreas may have different properties and a future study of in situ tumor is likely needed to determine whether the tumor tissue retains a structural remnant of its originating tissue. Methods and Materials Histology Sample Preparation Samples of normal human pancreas from five patients and pancreatic ductal adenocarcinoma tissue samples from ten patients were obtained with informed consent and institutional approval (University Health Network Toro...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Objectives Pancreatic ductal adenocarcinoma (PDAC) is the projected second leading cause of cancer related deaths within the next decade and it is characterized by a high rate of metastasis formation. Carcinoma cells which disseminate to distant organs can undergo a process which is called epithelial-to-mesenchymal transition (EMT) to gain invading properties. PDAC cells that undergo EMT express a variety of marker genes, such as EMT transcription factors (e.g. Snail, Slug, Twist 1/2, Zeb1/2) as well as fibroblast markers, such as collagens or Fsp1.
Source: Pancreatology - Category: Gastroenterology Authors: Tags: 4. Experimental pancreatitis and cell biology II Source Type: research
CONCLUSIONS Although preoperative diagnosis may be difficult, AIP with CG should be considered as a differential diagnosis in pancreatic cysts involving nodular lesions.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Abstract Lymph node involvement in pancreatic adenocarcinoma (PAC) predicts postresection survival, but early lymph node metastasis detection is not easily accomplished. We assessed a panel of microRNAs (miRNAs) in a common hepatic artery lymph node (station 8) that is readily accessible during pancreatoduodenectomy (PD) to determine if increased miRNA levels correlate with postresection recurrence. Station 8 lymph nodes overlying the common hepatic artery collected during PD were assayed for miRNA-10b, miRNA-30c, miRNA-21, and miRNA-155 and cytokeratin-19 (CK19), an epithelial cell marker, using quantitative PCR. Express...
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Databases & Libraries | Epithelial Cancer | Gastroenterology | Genetics | Pancreas | Pancreatic Cancer | Pancreatitis | Study