Gastrointestinal Failure Is a Predictor of Poor Outcome in Patients with Acute Pancreatitis

AbstractObjectiveAlthough gastrointestinal dysfunction is common in patients with acute pancreatitis, its impact on the outcome of disease has not been adequately studied. The present study was conducted to study the frequency of gastrointestinal failure (GIF) as well as its effect on outcome in patients with acute pancreatitis.MethodsPatients with acute pancreatitis admitted in our unit were prospectively studied. Gastrointestinal dysfunction and intra-abdominal pressures were measured daily till their resolution, and gastrointestinal failure score was calculated. Baseline parameters including various severity scores were noted. The patients were followed till clinical recovery or death.ResultsSixty-four patients (mean age 41.52  ± 16.28 years; 45 (70.3%) males) were prospectively studied. Forty-five (70.3%) patients had severe disease, and 18 (28.1%) patients succumbed to illness. GIF was present in 31 (48.4%) patients. The median duration of GIF was 5 (range 1–20) days. The presence of GIF was significantly associ ated with mortality (p value  
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research

Related Links:

Conclusion: In conclusion, Frey's procedure appears to be a less burdensome surgical procedure. Thus, it could be the first option for management of patients with large pancreatic stone. PMID: 31824884 [PubMed]
Source: Annals of Surgical Treatment and Research - Category: Surgery Tags: Ann Surg Treat Res Source Type: research
Conclusion: The present findings have demonstrated the beneficial protective and therapeutical effects of ruscogenin, nominating it as a highly promising supplementary agent to be considered in the treatment of AP, and even as a protective agent against the damages induced by disease. PMID: 31824881 [PubMed]
Source: Annals of Surgical Treatment and Research - Category: Surgery Tags: Ann Surg Treat Res Source Type: research
This study was designed to investigate characteristics of the disease to predict recurrence.Methods: We retrospectively analyzed 617 patients that experienced a first AP attack between January 2009 and December 2014. Based on reviews of clinical and follow-up data, we attempted to identify risk factors of recurrence using Cox regression analysis.Results: During a median follow-up of 3.2 years (range 3-72 months), 100(16.2%) of the 617 study subjects experienced one or more episodes of recurrent acute pancreatitis (RAP). Of these 100 patients, 75(75%) experienced one relapse, 12(12%) two relapses, and 13(13%) ...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
A 29-year-old woman, G2P1001, presented with irregular vaginal bleeding for 7 weeks 2 days and a serum beta-hcg level of 3000 mIU/mL. The patient had previously undergone two open abdominal surgeries for necrotizing pancreatitis four years ago. Abdominal and bimanual examinations revealed the prior inverted U-shaped surgical scar (Figure 1) and a normal size uterus without any tenderness or pain.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: IMAGES IN Gynecological Surgery Source Type: research
Condition:   Acute Pancreatitis Intervention:   Device: Echocardiograghy, ECG Sponsor:   Assiut University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
CONCLUSIONS: These findings support further development of HMI for clinical applications in disease staging and treatment response assessment in pancreatic ductal adenocarcinoma. PMID: 31831559 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
Condition:   Acute Pancreatitis Intervention:   Drug: CM4620 Sponsors:   St. Jude Children's Research Hospital;   CalciMedica, Inc. Not yet recruiting
Source: - Category: Research Source Type: clinical trials
ConclusionsCertain radiomic features on CT imaging can differentiate patients with functional abdominal pain, RAP, and CP.
Source: European Journal of Radiology - Category: Radiology Source Type: research
Authors: Fujisawa T, Isayama H, Gunji T, Sato H, Matsuhashi N Abstract Objectives To clarify the significance of ultrasonographically recorded pancreatic duct dilatation. Methods Various parameters predicting pancreatic disease were evaluated in relation to pancreatic duct dilatation using data from medical checkups of healthy examinees. Results Records of 281,384 subjects were analyzed. Pancreatic duct dilatation ( ≥3 mm) was determined ultrasonographically in 524 patients (0.19%). Subsequent detailed examinations revealed the presence of pancreatic disease in 24.8% of these patients, including pancreatic cysts...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
More News: Gastroenterology | Pancreatitis | Study