Activation of the HIF1 α/PFKFB3 stress response pathway in beta cells in type 1 diabetes

Conclusions/interpretationThe conserved pro-survival HIF1 α-mediated injury-response signalling is activated in beta cells in type 1 diabetes and likely contributes to the relatively slow rate of beta cell loss at the expense of early defective glucose-induced insulin secretion.
Source: Diabetologia - Category: Endocrinology Source Type: research