Synthesis and characterization of mesoporous SBA-15 and SBA -16 as carriers to improve albendazole dissolution rate

Publication date: Available online 13 November 2019Source: Saudi Pharmaceutical JournalAuthor(s): María Esperanza Adrover, Marisa Pedernera, Magali Bonne, Bénédicte Lebeau, Verónica Bucalá, Loreana GalloAbstractAlbendazole (ABZ, anti-parasitic active pharmaceutical ingredient) is a crystalline low water-soluble drug, thus the dissolution rate in gastrointestinal fluids is limited. Consequently, the improvement of the water solubility and dissolution rate of ABZ implies a great challenge for a more efficient treatment of hydatidosis. In this context, SBA-15 and SBA-16 ordered mesoporous silica materials were synthetized and loaded with ABZ. X-ray diffraction, FT-IR spectroscopy, nitrogen physisorption manometry, particle size distribution and scanning electronic microscopy were used to characterize unloaded and loaded materials (ABZ/SBA-15 and ABZ/SBA-16). The loaded ABZ amount in the carriers was estimated by elemental analysis. For the loaded materials, the drug solubility and release profile were evaluated. In addition, mathematical models were compared to explain the dissolution kinetics of ABZ from mesoporous solids.ABZ was successfully loaded into the mesopores. The amorphous state of the adsorbed ABZ was confirmed by differential scanning calorimetry that resulted in a notable increment in the dissolution rate compared to crystalline ABZ. Drug release behaviors were well simulated by the Weibull model for ABZ/SBA-15 and by the Gompertz...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research

Related Links:

Publication date: Available online 13 November 2019Source: Saudi Pharmaceutical JournalAuthor(s): María Esperanza Adrover, Marisa Pedernera, Magali Bonne, Bénédicte Lebeau, Verónica Bucalá, Loreana GalloAbstractAlbendazole (ABZ, anti-parasitic active pharmaceutical ingredient) is a crystalline low water-soluble drug, thus the dissolution rate in gastrointestinal fluids is limited. Consequently, the improvement of the water solubility and dissolution rate of ABZ implies a great challenge for a more efficient treatment of hydatidosis. In this context, SBA-15 and SBA-16 ordered mesoporous si...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 9 June 2019Source: International Journal for Parasitology: Parasites and WildlifeAuthor(s): Giovanni Sgroi, Antonio Varcasia, Giorgia Dessi, Nicola D'Alessio, Claudia Tamponi, Urmas Saarma, Teivi Laurimäe, Liina Kinkar, Mario Santoro, Vincenzo Caputo, Paolo Sarnelli, Giovanna Fusco, Paolo Varuzza, Alessandro Fioretti, Antonio Scala, Vincenzo VenezianoAbstractCystic Echinococcosis (CE) caused by Echinococcus granulosus sensu lato (s.l.) is one of the most important parasitic zoonotic diseases in the world and it represents an important public health and socio-economic concern. In the ...
Source: International Journal for Parasitology: Parasites and Wildlife - Category: Parasitology Source Type: research
This study aimed to analyze the demographic, clinical, diagnostic and therapeutic data of CE patients across all provinces in Iran. In this cross-sectional study, the mentioned data were routinely collected by provincial medical universities during the time from March 2016 to March 2017. The provincial population census was used to calculate the prevalence of CE per 1,000,000 populations for all provinces.T test and Chi squared test were used to compare variables between genders. Statistical analysis was done at 95% significant level using STATA 14 software. The overall prevalence of CE was 6.8 cases per 1,000,000 populati...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
ConclusionsThere was evidence for the existence of significant echinococcosis clusters in the Tibetan Region of Sichuan Province, China. The results of this study may assist local health departments with developing better prevention strategies and prompt more efficient public health interventions.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
Authors: Huang X, Wiehr S, Wild AM, Voßberg P, Hoffmann W, Grüner B, Köhler C, Soboslay PT Abstract Cytostatic drugs used in cancer therapy were evaluated for their capacity to inhibit Echinococcus multilocularis metacestode growth and proliferation. Metacestode tissues were exposed in vitro to docetaxel, doxorubicin, navelbine, paclitaxel, and vorinostat for 1 week, then incubated in drug-free culture, and thereafter metacestodes were injected into the peritoneum of Meriones unguiculatus. Magnetic resonance imaging (MRI) and simultaneous positron emission tomography (PET) were applied to monitor in...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Zheng J, Wang J, Zhao J, Meng X Abstract Objective: More than 70% of hepatic alveolar echinococcosis (HAE) are inoperable. Thus, long-term, or even life-long, pharmacological treatment with benzimidazoles is necessary. For effective treatment, it is of great importance to employ imaging techniques to detect and monitor the non-resectable parasitic viability. Therefore, this study aimed to evaluate diffusion-weighted imaging (DWI) in assessing the viability of HAE in comparison to 18-fluoro-deoxyglucose (18F-FDG) positron emission tomography, combined with computed tomography (PET/CT). Materials and Met...
Source: Korean Journal of Radiology - Category: Radiology Tags: Korean J Radiol Source Type: research
In conclusion, amino alcohols were a class of compounds with efficacy against E. granulosus. The most effective compounds JF16 and BTB4 indicated that their basic structure would be useful in the synthesis of new compound for the treatment of echinococcosis. However, their in vivo efficacy and toxicity need to be carefully evaluated in the future. PMID: 28859963 [PubMed - as supplied by publisher]
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
A 6-year-old girl presented with a 3-month history of progressive left-eye strabismus and vision loss. MRI scan of the brain showed a single hypointense lesion in the left cerebral hemisphere with no perilesional edema or contrast enhancement (figure 1, A–C). At surgery, the lesion was shown to be a single large parasitic cyst measuring approximately 7.0 x 6.5 x 6.0 cm (figure 2, A–C). The patient underwent a complete resection and then was given antihelminthic therapy. This resulted in an uneventful recovery. Pathology confirmed a diagnosis of brain cyst with scolex. This imaging feature of giant cystic echino...
Source: Neurology - Category: Neurology Authors: Tags: Medical care, MRI, Parasitic infections, Post-infectious, Central pain RESIDENT AND FELLOW SECTION Source Type: research
A 37-year-old Tibetan shepherdess presented with headache and weakness of the lower limbs for 10 months. Examination disclosed a positive straight-leg-raising test. Neuroimaging showed a heterogeneous mass in the left temporal lobe (figure 1) and an intradural mass in the lumbosacral canal with L4 vertebral body destruction (figure 2). Chest and abdominal CT scans were negative. Two operations yielded a tissue diagnosis of alveolar echinococcosis and postoperative albendazole therapy was started. Simultaneous involvement of brain and the spinal cord in primary extrahepatic alveolar echinococcosis is rare. Early diagnosis a...
Source: Neurology - Category: Neurology Authors: Tags: CT, MRI, Parasitic infections, Spinal cord infection NEUROIMAGES Source Type: research
In this study, we aim to investigate the efficiency and safety of radiotherapy for treating hydatid disease caused byEchinococcus granulosus in naturally infected sheep.MethodsUltrasound was used to screen naturally infected sheep in an echinococcosis endemic area in Xinjiang, China. A computer tomography (CT) scan confirmed the presence of hydatid cysts. Twenty sheep naturally infected withE. granulosus in the liver and/or lungs were randomly assigned into four groups receiving no irradiation, or X-ray irradiation of low (30  Gy), medium (45 Gy), and high dose (60 Gy), respectively. After three months of ra...
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
More News: Drugs & Pharmacology | Echinococcosis | Gastroenterology | Middle East Health | Parasitic Diseases | Parasitology | PET Scan | Saudi Arabia Health